血管生成拟态在子宫内膜癌组织中的表达及意义

发布时间：2018-04-21 05:52

本文选题：子宫内膜癌 + 血管生成拟态　；参考：《中国肿瘤临床》2015年23期

【摘要】：目的:探讨血管生成拟态(vasculogenic mimicry,VM)在子宫内膜癌中的表达及其与临床病理特征和预后的关系。方法:收集解放军白求恩国际和平医院2005年1月至2014年6月术后随访资料完整的子宫内膜癌标本267例,采用CD31/PAS双重染色鉴定VM结构,分为VM阳性组与VM阴性组,免疫组织化学SP法检测CD133的表达。结果:267例子宫内膜癌患者中65例(24.3%)存在VM。VM的形成与子宫内膜癌FIGO分期(χ2=9.987,P=0.002),组织学分级(χ2=11.795,P=0.001),肌层浸润深度(χ2=5.499,P=0.019),脉管内有无癌栓(χ2=22.599,P0.001)及淋巴结有无转移(χ2=7.848,P=0.005)密切相关。Kaplan-Meier法生存分析发现VM阳性组生存时间(中位生存时间为51个月)明显低于VM阴性组(中位生存时间为100个月),二者比较差异具有统计学意义(χ2=70.973,P0.001)。CD133在VM阳性组的表达率为75.4%(49/65),较VM阴性组58.9%(119/202)高,二者比较差异具有统计学意义(χ2=5.720,P=0.017)。结论:VM与子宫内膜癌的发生、发展及恶性度密切相关,是影响患者预后的重要指标,CD133表达阳性的肿瘤干细胞可能参与子宫内膜癌VM的形成。
[Abstract]:Objective: to investigate the expression of vasculogenic mimicrysia (VMM) in endometrial carcinoma and its relationship with clinicopathological features and prognosis. Methods: 267 cases of endometrial carcinoma with complete data were collected from Bai Qiuen International Peace Hospital of PLA from January 2005 to June 2014. VM structure was identified by CD31/PAS double staining and divided into VM positive group and VM negative group. Immunohistochemical SP method was used to detect the expression of CD133. Results VM.VM was found in 65 out of 267 endometrial carcinoma patients (蠂 29.987 P0. 002), histologic grade (蠂 2 / 11.795P ~ 0.001), depth of myometrium invasion (蠂 ~ 25.499P ~ (0.019)), tumor embolus (蠂 ~ 2 ~ 222.599p 0.001) and lymph node metastasis (蠂 ~ 27.848 P ~ (0.005)). Kaplan-Meier method was used to evaluate the survival score of endometrial carcinoma (蠂 ~ 27.848) and lymph node metastasis (蠂 ~ (27.848) P0. 005). The mean survival time of VM positive group (median survival time was 51 months) was significantly lower than that of VM negative group (median survival time was 100 months). The difference between the two groups was statistically significant (蠂 2 + 70.973 P 0.001N. CD133 expression rate in VM positive group was 75.4% 65%, higher than that in VM negative group 58.9% 119P 2022). The difference between the two groups was statistically significant (蠂 ~ 2 = 5.720, P = 0.017). Conclusion the tumor stem cells with positive expression of CD133 may be involved in the formation of VM in endometrial carcinoma, which is closely related to the occurrence, development and malignancy of endometrial carcinoma.
【作者单位】：解放军白求恩国际和平医院妇科;石家庄市妇幼保健院妇产科;
【分类号】：R737.33

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