子宫内膜样腺癌中低氧诱导因子-1α、-2α和Survivin的表达

发布时间：2018-04-23 19:42

本文选题：子宫内膜样腺癌 + 低氧诱导因子(HIF)-α　；参考：《中国老年学杂志》2015年20期

【摘要】：目的检测子宫内膜样腺癌术后组织中低氧诱导因子(HIF)-1α、2α和生存素(Survivin)的表达特征。方法 64例子宫内膜样腺癌患者的临床资料和术后蜡块组织作为观察组,56例子宫脱垂行子宫全切术后的子宫内膜组织作为对照组。应用免疫组化SP法检测两组中HIF-1α、-2α和Survivin的表达。结果两组中HIF-1α、-2α和Survivin表达的阳性率差别显著。观察组中HIF-1α、-2α和Survivin的阳性率均与肿瘤最大径及肌层浸润深度密切相关,HIF-1α、-2α的表达与肿瘤的分化程度密切相关。线性相关分析显示观察组中HIF-1α和Survivin、HIF-2α和Survivin的表达具有正相关性。结论子宫内膜样腺癌术后组织中HIF-1α、-2α和Survivin高表达,三者对促进肿瘤的形成和进展均有重要作用。HIF-1α、-2α均与Survivin有协同正向作用。
[Abstract]:Objective to detect the expression of hypoxia inducible factor (HIF-1 伪) and survivin (survivin) in endometrioid adenocarcinoma after operation. Methods the clinical data of 64 patients with endometrial adenocarcinoma and the postoperative wax tissue were used as the control group in which 56 cases of uterine prolapse after hysterectomy were used as the control group. Immunohistochemical SP method was used to detect the expression of HIF-1 伪 -2 伪 and Survivin in the two groups. Results the positive rates of HIF-1 伪-2 伪 and Survivin expression were significantly different between the two groups. The positive rates of HIF-1 伪 -m-2 伪 and Survivin were closely related to the maximum diameter of tumor and the depth of myometrial invasion. The expression of HIF-1 伪 -m-2 伪 was closely related to the degree of tumor differentiation. Linear correlation analysis showed that there was a positive correlation between the expression of HIF-1 伪 and survivin HIF-2 伪 and Survivin in the observation group. Conclusion the expression of HIF-1 伪 -m-2 伪 and Survivin is high in endometrioid adenocarcinoma after operation, which plays an important role in promoting tumor formation and progression. HIF-1 伪 -m-2 伪 has synergistic positive effect with Survivin.
【作者单位】：青海红十字医院妇三科;
【分类号】：R737.33

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