卵巢癌患者血清HE4、CA125水平变化及临床意义

发布时间：2018-04-24 00:15

本文选题：卵巢癌 + 人附睾分泌蛋白　；参考：《山东医药》2017年12期

【摘要】：目的探讨卵巢癌患者血清人附睾分泌蛋白4(HE4)、糖类抗原125(CA125)水平变化及临床意义。方法选择卵巢癌患者88例(卵巢癌组)、卵巢良性肿瘤患者195例(卵巢良性肿瘤组)、体检健康者132例(对照组)。对照组入院时、卵巢良性肿瘤组手术前、卵巢癌组手术前及手术后1周进行血清HE4、CA125水平检测,分析卵巢癌组血清HE4、CA125水平与患者临床病理参数的关系。采用受试者工作特征(ROC)曲线分析血清HE4、CA125单独或联合检测对卵巢癌的诊断价值。结果卵巢癌组血清CH4、CA125水平均明显高于对照组及卵巢良性肿瘤组(P均0.01),卵巢良性肿瘤组血清HE4水平高于对照组(P0.05)。卵巢癌组血清HE4、CA125水平均与肿瘤临床分期、病理类型有关(P0.05或0.01)。卵巢癌组术前血清HE4、CA125水平均高于术后1周(P均0.05)。ROC曲线结果显示,HE4诊断卵巢癌的特异性和阳性预测值均高于CA125(P均0.05),HE4、CA125联合检测诊断卵巢癌的敏感性及阳性预测值均高于HE4、CA125单独检测(P均0.05)。结论卵巢癌患者血清CA125、HE4水平均升高,二者联合检测可提高卵巢癌的诊断水平,并有助于判断卵巢癌的病理类型、临床分期及评估手术效果。
[Abstract]:Objective to investigate the changes and clinical significance of serum levels of human epididymal secretory protein (HE4) and carbohydrate antigen 125 (CA125) in patients with ovarian cancer. Methods 88 patients with ovarian cancer (ovarian cancer group), 195 patients with ovarian benign tumor (ovarian benign tumor group) and 132 healthy persons (control group) were selected. The serum levels of HE4CA125 were measured before operation and 1 week after operation in the benign ovarian tumor group and the control group, and the relationship between the serum HE4T CA125 level and the clinicopathologic parameters of the ovarian cancer group was analyzed. The diagnostic value of serum HE4 and CA125 in ovarian cancer was analyzed by using ROC curve. Results the serum levels of CH4 and CA125 in ovarian cancer group were significantly higher than those in control group and benign ovarian tumor group (P 0.01). The serum HE4 level in ovarian benign tumor group was higher than that in control group (P 0.05). The serum levels of HE4 and CA125 were correlated with the clinical stage and pathological type of ovarian cancer (P0.05 or 0.01). The preoperative serum levels of HE4ACA125 in ovarian cancer patients were higher than those in patients with ovarian cancer 1 week after operation. The results of 0.05).ROC curve showed that the specificity and positive predictive value of serum HE4 CA125 in diagnosis of ovarian cancer were higher than that of CA125(P in diagnosis of ovarian cancer. The sensitivity and positive predictive value of combined detection of HE4CA125 and HE4CA125 were higher than those of CA125(P in diagnosis of ovarian cancer. P was detected separately in HE4 and CA125. Conclusion the serum CA125 and HE4 levels in patients with ovarian cancer are all elevated. The combined detection of CA125 and HE4 may improve the diagnostic level of ovarian cancer, and be helpful to judge the pathological type, clinical stage and evaluate the operative effect of ovarian cancer.
【作者单位】：广东省中医院;广州中医药大学第二临床医学院;
【基金】：国家自然科学基金资助项目(81403422)
【分类号】：R737.31

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