血清IL-6和IL-8与TNF-α联合检测在胎膜早破早期宫内感染预测中的价值研究

发布时间：2018-04-24 01:27

本文选题：血清 + IL-　；参考：《中华医院感染学杂志》2017年05期

【摘要】：目的研究血清IL-6、IL-8与TNF-α联合检测在胎膜早破早期宫内感染预测中的价值,为胎膜早破早期宫内感染的诊断及防治提供参考。方法选取2014年6月-2015年12月医院收治40例胎膜早破早期宫内感染者为A组,40例胎膜早破未发生早期宫内感染者为B组,40例健康孕妇为C组,然后比较三组血清IL-6、IL-8与TNF-α水平,并比较A组与B组足月与未足月者的检测结果、A组不同严重程度绒毛膜羊膜炎者的检测结果。结果 A组血清IL-6、IL-8与TNF-α水平分别为(13.56±1.42)pg/ml、(15.78±1.69)pg/ml与(2.29±0.24)ng/ml,均高于B组(10.04±1.20)pg/ml、(12.53±1.42)pg/ml、(1.66±0.18)ng/ml及C组的(6.42±0.67)pg/ml、(7.85±0.78)pg/ml、(0.91±0.13)ng/ml,B组的检测水平则高于C组,同时A组足月与未足月者的检测结果均高于B组,A组不同严重程度绒毛膜羊膜炎者的检测结果比较,差异有统计学意义(P0.05)。结论血清IL-6、IL-8与TNF-α联合检测在胎膜早破早期宫内感染及其严重程度的预测价值较高。
[Abstract]:Objective to study the value of serum IL-6, IL-8 and TNF- alpha in the prediction of early intrauterine infection of premature rupture of membranes, and to provide a reference for the diagnosis and prevention of early intrauterine infection of premature rupture of membranes. Methods in December, June 2014, 40 cases of intrauterine infection with premature rupture of membranes were treated in group A, and 40 cases of premature rupture of membranes did not have early intrauterine sensation. The patients were group B, 40 healthy pregnant women were group C, and then compared the level of serum IL-6, IL-8 and TNF- alpha in the three groups, and compared the test results of A and B group for full month and non term, A group with different severity of chorionic amnionitis. Results the A group serum IL-6, IL-8 and TNF- alpha water was (13.56 + 1.42), (15.78 + 1.69), 2.29 and 2.29. Ng/ml (+ 0.24)) was higher than that of group B (10.04 + 1.20) pg/ml, (12.53 + 1.42) pg/ml, (1.66 + 0.18) ng/ml and C group (6.42 + 0.67) pg/ml, (7.85 + 0.78) pg/ml, (0.91 + 0.13) ng/ml, and the detection level of B group was higher than that of C group. The difference was statistically significant (P0.05). Conclusion the combined detection of serum IL-6, IL-8 and TNF- alpha was more valuable in predicting the early intrauterine infection and the severity of premature rupture of the membranes.

【作者单位】：新乡医学院第二附属医院检验科;新乡市第二人民医院妇产科;
【基金】：河南省科技发展计划基金资助项目(0224630164)
【分类号】：R714.433

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