益生菌治疗妇科恶性肿瘤患者化疗相关性腹泻的疗效观察

发布时间：2018-04-24 05:26

本文选题：益生菌 + 妇科恶性肿瘤　；参考：《基因组学与应用生物学》2017年11期

【摘要】：探讨益生菌对妇科恶性肿瘤患者化疗相关性腹泻(CID)的治疗效果。选择本院2016年2月~6月因妇科恶性肿瘤住院并发生CID的患者共126例,使用随机数字表将研究对象随机分为对照组和实验组,其中对照组63例,按照常规治疗(洛哌丁胺),实验组63例,在对照组基础上使用益生菌治疗;观察指标主要为患者平均腹泻持续时间、腹泻临床治疗效果、不良反应、KPS评分和免疫指标。对照组腹泻持续时间为(4.85±0.22)d,高于实验组(2.92±0.16)d,差异有统计学意义(p0.05);实验组总有效率为92.06%,高于对照组76.19%,差异有统计学意义(p0.05);实验组和对照组治疗后均有2例出现不良反应,差异无统计学意义(p0.05);治疗后实验组KPS评分为86分,高于对照组75分,差异有统计学意义(p0.05);实验组的CD3+、CD4+、CD4+/CD8+明显高于对照组,差异有统计学意义(p均0.05),但实验组和对照组CD8+的含量并没有统计学意义(p0.05)。益生菌可缩短妇科恶性肿瘤CID患者的腹泻持续时间,提高临床治疗效果,改善患者健康状况,提高患者的免疫力,值得在临床广泛推广使用。
[Abstract]:To investigate the therapeutic effect of probiotics on chemotherapy-associated diarrhea (CID) in patients with gynecological malignant tumor. A total of 126 patients with CID from February to June 2016 were selected. The subjects were randomly divided into control group and experimental group, including 63 cases in control group. According to the routine treatment (Lupibutylamine, 63 cases in the experimental group, treated with probiotics on the basis of the control group), the main indicators were the mean duration of diarrhea, the effect of clinical treatment of diarrhea, the score of adverse reactions and KPS score and the immune index. The duration of diarrhea in the control group was 4.85 卤0.22 days, which was higher than that in the experimental group (2.92 卤0.16 days), the difference was statistically significant (p 0.05), the total effective rate of the experimental group was 92.06g, higher than that of the control group 76.19g (P 0.05). After treatment, the KPS score of the experimental group was 86, which was higher than that of the control group (75), the difference was statistically significant (p 0.05), the CD3 CD4 / CD8 of the experimental group was significantly higher than that of the control group. The difference was statistically significant (P < 0.05), but there was no significant difference in the content of CD8 between the experimental group and the control group (P 0.05). Probiotics can shorten the duration of diarrhea in CID patients with gynecological malignancy, improve the clinical treatment effect, improve the health status of patients and improve the immunity of patients.
【作者单位】：盘锦职业技术学院;大连医科大学附属第二人民医院;
【基金】：盘锦职业技术学院对本研究的资助
【分类号】：R737.3

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