早孕期规范化超声检查在胎儿畸形筛查中的应用价值

发布时间：2018-04-24 11:26

  本文选题：早孕期 + 颈项透明层　； 参考：《安徽医科大学学报》2015年05期

【摘要】：目的探讨早孕期规范化超声检查在胎儿畸形筛查中的应用价值。方法选取行11~13+6周早孕期筛查的孕妇2 670例,采用常规经腹探查,按规范化序贯方法观察胎儿整体解剖结构并测量颈项透明层(NT)厚度,对阳性病例追踪随访至产后,并将严重畸形结果与引产后病理做对照分析。结果发现畸形胎儿17例,包含畸形总数27例,其中脊柱侧弯1例,无脑儿2例,露脑畸形1例,无叶全前脑1例,颈部水囊瘤6例,唇腭裂1例,胎儿水肿9例,心脏异常2例,脐膨出2例,下肢发育异常1例,巨膀胱1例,除2例心脏结构异常外均经引产证实。NT值≥3.0 mm 32例,其中染色体异常3例(羊水穿刺证实2例为21-三体综合征、1例为18-三体综合征)、颈部水囊瘤6例、全身水肿3例、胎死宫内1例,余产后正常。另检出5例鼻骨缺失,2例经羊水穿刺证实为21-三体综合征,1例胎死宫内,2例产后正常。结论早孕期规范化检查可以较早发现胎儿严重结构畸形,对产前诊断具有较大临床应用价值。NT值增厚对于早期评估染色体异常风险及指导预后有显著意义。
[Abstract]:Objective to investigate the application value of standardized ultrasonography in early pregnancy in fetal malformation screening. Methods A total of 2670 pregnant women were selected for early pregnancy screening at 11136-week. The fetal whole anatomical structure was observed and the thickness of the transparent layer of the neck was measured according to the standardized sequential method. The positive cases were followed up to the postpartum period. The results of severe malformation were compared with the pathology after induced labor. The results showed that there were 17 cases of malformed fetus, including 27 cases of malformation, including 1 case of scoliosis, 2 cases of anencephaly, 1 case of deformity, 1 case of anencephaly, 1 case of anencephaly, 6 cases of cervical hydrocystoma, 1 case of cleft lip and palate, 9 cases of fetal edema. There were 2 cases of cardiac abnormality, 2 cases of omphalocele, 1 case of lower extremity dysplasia, 1 case of giant bladder, 32 cases of which were proved by induced labor to be 鈮，

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