微刺激全部胚胎冷冻方案在常规体外受精-胚胎移植失败的卵巢低反应患者中的应用

发布时间：2018-04-24 18:10

  本文选题：微刺激方案 + 卵巢低反应(POR)　； 参考：《中华生殖与避孕杂志》2017年08期

【摘要】：目的探讨微刺激全部胚胎冷冻方案在常规体外受精/卵胞质内单精子显微注射-胚胎移植(IVF/ICSI-ET)方案失败的卵巢低反应(POR)患者中的应用价值。方法对196例IVF/ICSI-ET应用常规促排卵方案因POR放弃周期或移植失败后改用微刺激方案的402个周期进行回顾性分析,比较前、后2次不同促排卵方案的临床和实验室指标。结果 402个微刺激周期中32个周期取消,周期取消率为7.96%,370个周期获得卵母细胞,平均获卵数(2.2±1.5)个,共233个周期有胚胎冷冻,胚胎冷冻率为57.96%,共194个周期进行了ET,临床妊娠74例,早期自然流产6例,起始周期累积妊娠率为37.75%(74/196),冻融胚胎移植(FET)周期临床妊娠率为38.14%(74/194),其中≤37岁组FET周期的临床妊娠率(50.89%)明显高于37岁组(20.73%)(P0.05)。微刺激方案的临床和实验室指标均显著优于常规长方案。结论微刺激全部胚胎冷冻方案对常规方案IVF/ICSI-ET治疗失败的POR患者具有疗程短、刺激剂量小,获卵率高、可利用胚胎率高、周期取消率低等特点,对于该类患者再次助孕可考虑微刺激方案。
[Abstract]:Objective to investigate the value of microstimulation of all embryo freezing protocols in patients with ovarian hyporesponse (POR) after IVF / ICSI-ETT failed in vitro fertilization / intracytoplasmic sperm microinjection (IVF / ICSI-ETT). Methods the clinical and laboratory indexes of 196 patients with IVF/ICSI-ET who were treated with conventional ovulation stimulation regimen because of POR abandoning cycle or failed transplantation were analyzed retrospectively. The clinical and laboratory indexes of different ovulation promotion protocols were compared before and after the ovulatory therapy. Results 32 cycles of 402 microstimulation cycles were cancelled, the cycle cancellation rate was 7.96. The oocytes were obtained in 370 cycles. The average number of oocytes was 2.2 卤1.5. There were 233 cycles with embryo freezing. The embryo freezing rate was 57.96. ETS were performed in 194 cycles. 74 clinical pregnancies were performed. In 6 cases of early spontaneous abortion, the cumulative pregnancy rate of initial cycle was 37.75 / 74 / 196, and the clinical pregnancy rate of frozen-thawed embryo transfer transfer (fet) cycle was 38.14 / 194%. The clinical pregnancy rate of FET cycle in group 鈮，

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