卵巢癌中Ezrin、Paxillin及CD44的表达及与临床病理参数的相关性

发布时间：2018-04-25 00:35

本文选题：卵巢癌 + 埃兹蛋白(Ezrin)　；参考：《中国老年学杂志》2017年23期

【摘要】：目的探讨埃兹蛋白(Ezrin)、桩蛋白(Paxillin)及CD44在卵巢癌中的表达及其与临床病理参数的相关性。方法选取卵巢癌组织120例,良性卵巢肿瘤组织100例,正常卵巢组织100例,应用免疫组化SP法检测不同组织中Ezrin、Paxillin及CD44蛋白的表达,分析其表达与临床病理参数的关系,并采用Spearman等级相关分析卵巢癌组织中Ezrin、Paxillin及CD44的相关性。结果卵巢癌组织中Ezrin、Paxillin及CD44的阳性表达率均高于良性卵巢肿瘤及正常卵巢组织(均P0.05)。Ezrin、Paxillin阳性表达率与卵巢癌手术病理分期及腹水转移有关(P0.05),与分化程度、病理类型无关(P0.05);CD44阳性表达率与卵巢癌手术病理分期、分化程度及腹水转移有关(P0.05),与病理类型无关(P0.05)。Spearman等级相关分析显示,卵巢癌组织Ezrin的阳性表达率与Paxillin及CD44的阳性表达率呈正相关(Rs=0.843,0.672;均P0.05)。结论临床上可通过检测Ezrin、Paxillin及CD44蛋白表达明确患者病情恶化情况。
[Abstract]:Objective to investigate the expression of Ezrinin (Paxillin) and CD44 in ovarian cancer and its correlation with clinicopathological parameters. Methods 120 cases of ovarian cancer, 100 cases of benign ovarian tumor and 100 cases of normal ovarian tissue were selected. The expression of Ezrinn paxillin and CD44 protein in different tissues was detected by immunohistochemical SP method, and the relationship between the expression and clinicopathological parameters was analyzed. The correlation between Ezrintin paxillin and CD44 in ovarian cancer tissues was analyzed by Spearman rank correlation. Results the positive expression rates of Ezrinin paxillin and CD44 in ovarian cancer tissues were higher than those in benign ovarian tumors and normal ovarian tissues. The positive expression rate of CD44 was not related to the pathological stage, differentiation and ascites metastasis of ovarian cancer, but not to the pathological type (P 0.05). Spearman grade correlation analysis showed that the expression of CD44 was related to the pathological stage, differentiation and ascites metastasis of ovarian cancer. There was a positive correlation between the positive expression rate of Ezrin and the positive rate of Paxillin and CD44 in ovarian cancer tissues. Conclusion the expression of Ezrinin paxillin and CD44 protein can be detected in clinic.
【作者单位】：绍兴市上虞人民医院妇科;浙江大学医学院附属妇产科医院妇科;
【分类号】：R737.31

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