多囊卵巢综合征临床干预前后血清内脂素变化及相关因素研究

发布时间：2018-04-25 04:17

本文选题：多囊卵巢综合征 + 内脂素　；参考：《中国妇幼保健》2016年04期

【摘要】：目的研究多囊卵巢综合征(PCOS)患者临床干预前后血清内脂素水平变化及其在PCOS病理生理机制中可能发挥的作用。方法选取2012年8月-2013年9月该院生殖医学科71例PCOS患者为PCOS组,45例健康志愿者或在生殖医学中心行辅助治疗的为对照组。比较血清内脂素水平及相关因素;根据PCOS患者不同BMI及胰岛素抵抗指数(HOMA-IR)分组,检测不同组间血清内脂素水平差异;比较38例PCOS患者治疗前后血清内脂素、BMI、睾酮(T)、LH/FSH值及HOMA-IR变化。结果 71例PCOS患者总体血清内脂素水平低于对照组,但差异无统计学意义(P0.05),内脂素水平与HOMA-IR呈低度正相关(r=0.385,P0.01);对照组内脂素水平未发现与其他因素有明显相关性。PCOS各组内脂素水平和对照组无差别,仅PCOS肥胖患者血清内脂素水平显著低于对照组,差异有统计学意义(P0.05)。PCOS治疗后T、BMI、HOMA-IR及LH/FSH均显著降低,治疗前后差异均有统计学意义(P0.01),而内脂素水平较治疗前显著升高,差异有统计学意义(P0.05)。PCOS治疗前后血清内脂素水平变化与T、BMI、HOMA-IR及LH/FSH的变化均无明显相关性。结论肥胖PCOS患者内脂素水平低于对照组,PCOS患者经治疗干预后内分泌及代谢指标均得到改善,但内脂素水平升高,提示内脂素可能在改善PCOS患者临床指标上发挥作用。
[Abstract]:Objective to study the changes of serum lipid level in patients with polycystic ovary syndrome (PCOS) before and after clinical intervention and its possible role in the pathophysiological mechanism of PCOS. Methods from August 2012 to September 2013, 71 PCOS patients were selected as PCOS group (45 healthy volunteers) or as control group. The serum lipid levels and related factors were compared according to the different BMI and insulin resistance index (HOMA-IRR) of patients with PCOS, and the changes of serum lipopolysaccharide (BMI), testosterone (T) and HOMA-IR in 38 patients with PCOS before and after treatment were compared. Results the serum lipid levels in 71 patients with PCOS were lower than those in the control group. However, there was no significant difference (P 0.05), and the level of endolipidin was positively correlated with HOMA-IR (0.385% P 0.01), but there was no significant correlation between the level of lipid in the control group and other factors. There was no significant difference between the levels of lipoprotein in each group and that in the control group, but there was no significant difference between the two groups in the level of endolipidin and that in the control group. The serum levels of lipoprotein in obese patients with PCOS were significantly lower than those in the control group. The difference was statistically significant (P 0.05). The levels of HOMA-IR and LH/FSH in patients with PCOS were significantly lower than those in the control group. The difference before and after treatment was statistically significant (P 0.01), while the level of endolipidin was significantly higher than that before treatment. There was no significant correlation between the changes of serum lipid level and the changes of TBMIHOMA-IR and LH/FSH before and after treatment. Conclusion Endocrine and metabolic indexes in obese PCOS patients were lower than those in the control group, but the levels of endolipidins increased, suggesting that endolipidins may play an important role in improving the clinical indexes of PCOS patients.
【作者单位】：厦门市妇幼保健院生殖医学科;
【基金】：厦门市科技计划项目(3502Z20124058)
【分类号】：R711.75

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