炔雌醇环丙孕酮联合胰岛素增敏剂对多囊卵巢综合征患者内分泌功能的影响

发布时间：2018-04-25 07:23

本文选题：多囊卵巢综合征 + 炔雌醇环丙孕酮　；参考：《山东医药》2015年09期

【摘要】：目的探讨炔雌醇环丙孕酮联合胰岛素增敏剂(IS)对多囊卵巢综合征(PCOS)患者内分泌紊乱的干预作用。方法将80例POCS患者随机分为观察组和对照组各40例,对照组应用炔雌醇环丙孕酮治疗,观察组加用吡格列酮治疗。治疗前后检测两组血清去氢表雄酮硫酸盐(Ds)、性激素结合蛋白(SHBG)、雄烯二酮(A2)、雌二醇(E2)、睾酮(T)、黄体生成素(LH)、促卵泡生成素(FSH)、空腹胰岛素(FINS)、空腹血糖(FPG)、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)等指标并进行比较。结果两组E2、SHBG、Ds、A2、T均较治疗前改善(P0.05或0.01),观察组改善程度优于对照组(P均0.05)。结论炔雌醇环丙孕酮与IS联用降低PCOS患者体内胰岛素和雄激素水平,减轻胰岛素抵抗,改善机体的内分泌环境及提高卵巢功能。
[Abstract]:Objective to investigate the interventional effect of ethylestradiol cycloprogestrel combined with insulin sensitizer (ISI) on endocrine disorders in patients with polycystic ovary syndrome (PCOS). Methods Eighty patients with POCS were randomly divided into the observation group (n = 40) and the control group (n = 40). The control group was treated with estradiol cycloprogestrel and the observation group was treated with pioglitazone. Serum Dehydroepiandrosterone Sulfate (DsN), Sex hormone binding protein (SHBGN), androstenedione A2U, estradiol (E2N), testosterone (T), luteinizing hormone (LHN), FSH, fasting insulin (FINSN), fasting blood glucose (FFP), insulin resistance index (IGR) were detected before and after treatment. HOMA-IRN and insulin secretion index (Homa-尾) were compared. Results the results showed that the improvement of E2H SHBGN DsA2T in the two groups was better than that before treatment (P0.05 or 0.01), and the improvement degree in the observation group was better than that in the control group (P 0.05). Conclusion the combination of ethylestradiol cyproprogesterone and is can reduce insulin and androgen levels, alleviate insulin resistance, improve endocrine environment and improve ovarian function in patients with PCOS.
【作者单位】：唐山市妇幼保健院;
【分类号】：R711.75

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