胚胎围植入期的内膜血管新生相关研究进展

发布时间：2018-04-25 12:06

本文选题：胚胎植入 + 血管新生　；参考：《中华生殖与避孕杂志》2017年03期

【摘要】：胚胎在具有容受性的内膜中充分植入是成功妊娠的前提,胚胎植入是一个受到精确调控的生理过程,可概括为胚胎的定位、黏附和侵入3个阶段。血管新生贯穿于子宫内膜周期性变化和胚胎植入过程,并为胚胎的发育提供了重要的物质基础。本文就血管内皮生长因子(VEGF)、成纤维细胞生长因子(FGF)、转化生长因子(TGF)、血管生成素(Ang)、整合素(integrin)等血管新生相关因子,在胚胎植入前内膜准备和胚胎植入过程中的表达规律及子宫内膜血流灌注超声评价2个方面进行综述,为进一步干预血管新生过程,改善子宫内膜容受性和提高胚胎种植成功率奠定基础。
[Abstract]:Embryo implantation in receptive endometrium is the premise of successful pregnancy. Embryo implantation is a physiological process controlled by precision, which can be summarized as three stages of embryo localization, adhesion and invasion. Angiogenesis runs through the periodic changes of endometrium and embryo implantation, and provides an important material basis for embryo development. In this paper, angiogenic factors such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), transforming growth factor (TGFN), angiopoietin (Ang), integrin (integrin), and so on, were studied. In order to further interfere with angiogenesis, the expression of endometrial preparation and embryo implantation and the ultrasound evaluation of endometrial blood flow perfusion were reviewed. Improving endometrial receptivity and increasing the success rate of embryo implantation lay the foundation.
【作者单位】：苏州大学附属第一医院生殖中心;
【基金】：江苏省卫生厅项目(H201311) 苏州市卫生局科技项目(LCXZ201302) 苏州市医学重点学科(生殖医学)资助~~
【分类号】：R714.8

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