卵巢癌患者外周血D-二聚体、FIB水平与IL-6动态变化的研究

发布时间：2018-04-27 10:28

本文选题：纤维蛋白原 + IL-　；参考：《中国免疫学杂志》2015年04期

【摘要】：目的:探讨卵巢癌患者血浆D-二聚体、纤维蛋白原(FIB)、白细胞介素6(IL-6)动态变化及其对卵巢癌诊断中的价值和临床意义。方法:选择卵巢癌患者65例、35例卵巢良性肿瘤患者和30例健康体检者做对照,取卵巢癌患者和对照组的血清及血浆,用胶乳凝集法测定血浆中的D-二聚体、FIB含量,用ELISA法测定IL-6水平。结果:卵巢癌患者FIB、IL-6、D-二聚体水平明显高于对照组和卵巢良性肿瘤组,差异有显著统计学意义(P0.05);卵巢良性肿瘤患者FIB、IL-6、D-二聚体水平与正常对照组无显著差异(P0.05),癌症组FIB、IL-6、D-二聚体随着临床分期的升高而递增,相关性分析表明,FIB与IL-6、D-二聚体呈正相关(r=0.31,r=0.56)。结论:FIB、IL-6、D-二聚体联合检测对于卵巢癌的早期诊断、分期及判断预后具有重要的临床价值。
[Abstract]:Objective: to investigate the dynamic changes of plasma D-dimer, fibrinogen fibronectin (FIBN) and interleukin-6 (IL-6) in patients with ovarian cancer and their clinical significance in the diagnosis of ovarian cancer. Methods: 65 patients with ovarian cancer and 35 patients with benign ovarian tumor and 30 healthy controls were selected as control group. The serum and plasma of ovarian cancer patients and control group were collected and the levels of D- dimer FIB in plasma were determined by latex agglutination method. The level of IL-6 was measured by ELISA. Results: the level of IL-6 D dimer in ovarian cancer patients was significantly higher than that in control group and benign ovarian tumor group. There was no significant difference in the level of IL-6D- dimer between patients with ovarian benign tumor and normal control group (P 0.05). The level of IL-6D- dimer in cancer group was increased with the increase of clinical stage. The correlation analysis showed that FIB was positively correlated with IL-6D- dimer. Conclusion the combined detection of IL-6 D-dimer in FIBN has important clinical value for early diagnosis, staging and prognosis of ovarian cancer.
【作者单位】：唐山市妇幼保健院检验科;唐山市滦县人民医院妇科;
【分类号】：R737.31;R730.43

【参考文献】