系统性红斑狼疮妊娠患者早产的临床特点和危险因素分析
发布时间：2018-04-27 21:15
本文选题：系统性红斑狼疮 + 妊娠 ； 参考：《中山大学学报(医学科学版)》2016年06期
【摘要】：【目的】探讨系统性红斑狼疮(SLE)合并妊娠患者胎儿早产的临床特点以及危险因素。【方法】回顾性分析中山大学附属第一医院收治的251例SLE患者共计263例次合并妊娠临床资料进行回顾性分析。多因素分析采用Logistic回归模型进行。【结果】SLE孕妇妊娠时平均年龄为(28.6±3.9)岁(18~41岁)。共有188例(71.5%)活胎分娩,其中足月产132例(70.2%),早产56例(29.8%),另有75例(28.5%)发生妊娠丢失。34周的早产发生率为39.3%,≥34周的早产发生率为60.7%。早产的原因依次为治疗性早产(38例),自发性早产(10例)和未足月胎膜早破早产(8例)。早产儿死亡率为3.6%,均发生于34孕周的胎儿。胎儿脐动脉血流彩色多普勒超声检查提示早产儿脐动脉血流S/D值高于足月产儿(P㩳0.05)。多因素分析显示早产的危险因素是高血压(OR=5.7,95%CI 2.4~13.5,P0.001)和低蛋白血症(OR=4.1,95%CI 1.7~9.8,P=0.002)。【结论】SLE合并妊娠胎儿早产率高,治疗性早产是主要原因,34孕周的早产儿死亡率高。SLE患者妊娠期间合并高血压、低蛋白血症可增加胎儿早产的危险。胎儿脐动脉血流彩色多普勒超声可作为孕期监测手段。
[Abstract]:[objective] to investigate the clinical characteristics and risk factors of fetal preterm delivery in patients with systemic lupus erythematosus (SLE) complicated with pregnancy. [methods] A retrospective analysis of #number0# cases of SLE patients in the first affiliated Hospital of Sun Yat-sen University was made. The clinical data of pregnancy were analyzed retrospectively. Multivariate analysis was carried out by Logistic regression model. [results] the average age of pregnant women with SLE was 28.6 卤3.9 years old or 1841 years old. A total of 188 cases (71.5) were born with live fetus, including 132 cases of full-term delivery (70.2%), 56 cases of premature delivery (29. 8%) and 75 cases (75 cases) of loss of pregnancy. The incidence of preterm delivery at 34 weeks was 39.3%, and that of 鈮，
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