子宫内膜样腺癌中白细胞分化抗原74表达及其与上皮型黏附素的相关性

发布时间：2018-04-28 13:13

本文选题：子宫内膜样腺癌 + 白细胞分化抗原(CD)　；参考：《中国老年学杂志》2017年23期

【摘要】：目的观察子宫内膜样腺癌术后组织中白细胞分化抗原(CD)74和上皮型黏附素(E-cadherin)的表达及二者在不同临床病理特征中的表达差异,并分析其相关性。方法确诊为子宫内膜样腺癌患者的术后组织59例为观察组,24例子宫内膜复杂性增生的子宫内膜组织为对照组,24例子宫脱垂患者术后留取的子宫内膜组织为正常对照组,应用免疫组化SP法检测3组CD74和E-cadherin的表达。结果正常对照组、对照组和观察组中CD74表达有明显升高趋势,E-cadherin表达有明显下降趋势;观察组中CD74和E-cadherin表达与肿瘤淋巴结转移和肌层浸润深度密切相关,CD74与肿瘤分化程度和周围炎细胞浸润程度密切相关。相关分析显示观察组中CD74和E-cadherin表达呈负相关。结论子宫内膜样腺癌中CD74和E-cadherin异常表达是促进肿瘤形成和进展的重要因素,CD74和E-cadherin的相关性可能与肿瘤转移相关。
[Abstract]:Objective to observe the expression of leukocyte differentiation antigen (CDM74) and epithelial adhesion protein (E-cadherin) in endometrioid adenocarcinoma after operation, and to analyze the correlation between them in different clinicopathological features. Methods the postoperative tissues of 59 patients with endometrioid adenocarcinoma were divided into two groups: the control group (n = 24) with complicated endometrial hyperplasia and the control group (n = 24). Immunohistochemical SP method was used to detect the expression of CD74 and E-cadherin in three groups. Results the expression of E-cadherin in normal control group, control group and observation group was significantly increased. The expression of CD74 and E-cadherin was closely related to lymph node metastasis and depth of myometrial invasion in the observation group. CD74 was closely correlated with the degree of tumor differentiation and the degree of infiltration of peripheral inflammatory cells. Correlation analysis showed that the expression of CD74 and E-cadherin was negatively correlated in the observation group. Conclusion the abnormal expression of CD74 and E-cadherin in endometrial adenocarcinoma is an important factor to promote tumor formation and progression. The correlation between CD74 and E-cadherin may be related to tumor metastasis.
【作者单位】：牡丹江医学院附属红旗医院妇产科;
【分类号】：R737.33

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