卵巢癌中Tiam1蛋白过表达的临床病理学意义

发布时间：2018-04-28 17:36

本文选题：卵巢肿瘤 + Tiam　；参考：《临床与实验病理学杂志》2017年09期

【摘要】：目的探讨卵巢癌中Tiam1过表达的临床病理学意义。方法采用免疫组化SP两步法检测Tiam1蛋白在98例浆液性卵巢癌组织、64例黏液性囊腺癌组织以及27例良性病变组织中的表达,并分析其过表达与卵巢癌临床病理特征的关系。应用Kaplan-Meier进行生存分析。结果 Tiam1蛋白主要表达于卵巢癌细胞胞质和胞核中。在浆液性卵巢癌组织中,Tiam1蛋白的阳性率和强阳性率分别为84.7%(83/98)和70.4%(69/98);在黏液性囊腺癌组织中,Tiam1蛋白的阳性率和强阳性率分别为87.5%(56/64)和73.4%(47/64),显著高于良性卵巢肿瘤组织(22.2%和7.4%)(P均0.01)。Tiam1蛋白表达水平与卵巢癌组织学分级、FIGO分期和转移情况密切相关(P均0.05);与患者年龄及绝经情况无关(P均0.05)。Kaplan-Meier生存分析显示,Tiam1蛋白高表达的卵巢癌患者总生存期和无瘤生存期均明显低于Tiam1蛋白低表达患者(P均0.05),且Tiam1蛋白高表达的转移性卵巢癌患者总生存期也明显低于Tiam1蛋白低表达患者(P0.05)。结论 Tiam1蛋白在卵巢癌组织中明显高表达,其表达水平与卵巢癌患者的预后密切相关。
[Abstract]:Objective to investigate the clinicopathological significance of overexpression of Tiam1 in ovarian cancer. Methods Immunohistochemical SP two-step method was used to detect the expression of Tiam1 protein in 98 cases of serous ovarian carcinoma tissues, 64 cases of mucinous cystadenocarcinoma and 27 cases of benign lesions, and the relationship between overexpression and clinicopathological features of ovarian cancer was analyzed. Kaplan-Meier was used for survival analysis. Results Tiam1 protein was mainly expressed in cytoplasm and nucleus of ovarian cancer cells. The positive and strong positive rates of tiam1 protein in serous ovarian carcinoma were 84.3% and 70.4%, respectively, and those in mucinous cystadenocarcinoma tissues were 87.556 / 64 and 73.447 / 64 respectively, which were significantly higher than those in benign ovarian cancer tissues (22. 2%) and benign ovarian cancer tissues (22. 2%). 7.4The expression level of 0.01).Tiam1 protein was closely related to histological grade, Figo stage and metastasis of ovarian cancer, and had no relation with age and menopausal status. 0.05).Kaplan-Meier survival analysis showed that the total survival time of ovarian cancer patients with high expression of Tiam1 protein was higher than that of patients with ovarian cancer. The total survival time of metastatic ovarian cancer patients with high expression of Tiam1 protein was significantly lower than that of patients with low expression of Tiam1 protein. The total survival time of patients with metastatic ovarian cancer with high expression of Tiam1 protein was significantly lower than that of patients with low expression of Tiam1 protein. Conclusion the expression of Tiam1 protein is significantly higher in ovarian cancer tissues, and its expression level is closely related to the prognosis of ovarian cancer patients.
【作者单位】：延边大学医学院病理学教研室;
【基金】：国家自然科学基金(61371067)
【分类号】：R737.31

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