中西医结合治疗多囊卵巢综合征不孕症痰湿阻滞证临床研究

发布时间：2018-04-28 21:40

本文选题：多囊卵巢综合征(PCOS) + 不孕症　；参考：《新中医》2016年01期

【摘要】：目的:观察在常规西药治疗基础上,采用丹溪治湿痰方联合黄连素治疗多囊卵巢综合征(PCOS)不孕症痰湿阻滞证的疗效以及对血清瘦素(LP)和游离脂肪酸(FFA)水平的影响。方法:选取本院收治的116例PCOS不孕症患者,按随机数字表法分为治疗组和对照组各58例。所有患者给予炔雌醇环丙孕酮片和克罗米芬促排卵治疗,治疗组加用丹溪治湿痰方和黄连素片治疗。2组疗程均为4个月经周期。记录2组患者在6个月经周期内的临床妊娠率;比较2组的卵巢体积和子宫体部子宫内膜厚度,检测血清LP和FFA水平。结果:总妊娠率治疗组为62.07%,对照组为32.76%,2组比较,差异有统计学意义(P0.01)。治疗后,2组卵巢体积均减小(P0.01),子宫内膜厚度均增加(P0.01);治疗组卵巢体积小于对照组,子宫内膜厚度值大于对照组,差异均有统计学意义(P0.01)。治疗后,2组血清LP和FFA水平均较治疗前下降(P0.01);治疗组血清LP和FFA水平均低于对照组,差异均有统计学意义(P0.01)。结论:在常规西药治疗基础上,采用丹溪治湿痰方联合黄连素治疗PCOS不孕症痰湿阻滞证患者疗效显著,可缩小卵巢体积,同时增加子宫内膜厚度,提高临床妊娠率;降低患者血清LP和FFA水平可能是该疗法发挥上述疗效的机制之一。
[Abstract]:Objective: to observe the therapeutic effect of Danxi Zhishitan recipe combined with berberine on phlegm dampness block syndrome in infertility with polycystic ovary syndrome (PCOS) and the effect on serum leptin (LP) and free fatty acid (FFA) levels. Methods: 116 patients with PCOS infertility were randomly divided into treatment group (n = 58) and control group (n = 58). All patients were treated with ethylestradiol cycloprogestrel and clomiphene to promote ovulation. The treatment group was treated with Danxi Zhishitan recipe and berberine tablet for 4 menstrual cycles. The clinical pregnancy rates of the two groups were recorded during 6 menstrual cycles, the ovarian volume and endometrial thickness of the uterus were compared, and the serum LP and FFA levels were measured. Results: the total pregnancy rate was 62.07 in the treatment group and 32.76 in the control group. The difference was statistically significant (P 0.01). After treatment, the ovarian volume decreased and the endometrial thickness increased in both groups, and the ovarian volume in the treatment group was smaller than that in the control group, and the endometrial thickness value was higher than that in the control group (P 0.01). After treatment, the serum LP and FFA levels in the two groups were lower than those before treatment, and the levels of LP and FFA in the treatment group were lower than those in the control group (P 0.01). Conclusion: on the basis of routine western medicine treatment, Danxi Zhishitan prescription combined with berberine is effective in treating PCOS infertility with phlegm dampness block, which can reduce the volume of ovary, increase the thickness of endometrium and increase the clinical pregnancy rate. The reduction of serum LP and FFA levels may be one of the mechanisms of this therapy.
【作者单位】：温州医科大学;浙江中医药大学附属温州中西医结合医院妇产科;
【分类号】：R711.75

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