分娩前后凝血与纤溶指标的变化及与炎症因子的相关性

发布时间：2018-04-29 05:04

本文选题：分娩 + 产后出血　；参考：《中国妇产科临床杂志》2017年05期

【摘要】：目的探讨分娩前后凝血与纤溶指标的变化及及与炎症因子的相关性。方法收集2014年1月至2016年6月在江苏省无锡市妇幼保健院接受分娩产妇的临床资料,根据分娩后出血情况分为产后出血组和正常分娩组。比较两组产妇凝血、纤溶指标和炎症细胞因子并分析参数间的相关性。结果分娩前,与正常分娩组比,产后出血组FIB明显降低(P0.05),APTT、PT、TT和D-D明显增高(P0.05),两组IL-6、hs-CRP和TNF-α差异无统计学意义(P0.05);分娩后,与正常分娩组比,产后出血组FIB明显降低(P0.05),APTT、PT、TT、D-D、IL-6、hs-CRP和TNF-α明显增高(P0.05)。分娩前IL-6、hs-CRP和TNF-α与凝血、纤溶指标无相关性(P0.05);分娩后IL-6、hs-CRP和TNF-α与FIB呈负相关(P0.05),与APTT、PT、TT和D-D呈正相关(P0.05)。结论分娩前后,产后出血产妇的凝血和纤溶指标均有明显变化,均与炎症细胞因子存在相关性,可作为临床监测和预防产后出血的重要指标。
[Abstract]:Objective to investigate the changes of coagulation and fibrinolysis indexes before and after delivery and their correlation with inflammatory factors. Methods from January 2014 to June 2016, we collected the clinical data of parturient in Wuxi Maternal and Child Health Hospital, Jiangsu Province, and divided them into postpartum hemorrhage group and normal delivery group according to postpartum hemorrhage. The coagulation, fibrinolysis and inflammatory cytokines were compared between the two groups. Results before delivery, compared with the normal delivery group, the FIB in the postpartum hemorrhage group was significantly lower than that in the normal delivery group. The levels of FIB and D-D were significantly increased in the postpartum hemorrhage group. The levels of IL-6 hs-CRP and TNF- 伪 in the two groups were not significantly different from those in the normal delivery group (P 0.05). After delivery, FIB in the postpartum hemorrhage group was significantly lower than that in the normal delivery group, and the levels of FIB and TNF- 伪 were significantly higher in the postpartum hemorrhage group than in the normal delivery group. Before delivery, IL-6 hs-CRP and TNF- 伪 had no correlation with coagulation and fibrinolysis, but there was a negative correlation between IL-6 hs-CRP and TNF- 伪 and FIB (P0.05), and a positive correlation between IL-6 hs-CRP and D-D and PTTT and D-D. Conclusion the coagulation and fibrinolysis indexes of postpartum hemorrhage parturient have obvious changes before and after delivery, which are related to inflammatory cytokines, and can be used as an important index for clinical monitoring and prevention of postpartum hemorrhage.
【作者单位】：江苏省无锡市妇幼保健院产科;江苏省妇幼保健院产科;
【分类号】：R714.461

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