血浆可溶性晚期糖基化终末产物受体在妊娠期高血压性心脏病的表达及其临床意义

发布时间：2018-04-29 07:16

本文选题：高血压 + 妊娠性　；参考：《中国循环杂志》2017年09期

【摘要】：目的:探讨可溶性晚期糖基化终末产物受体(s RAGE)在妊娠期高血压性心脏病中的表达和临床意义。方法:选择2013-06至2016-07我院收治的57例符合妊娠期高血压性心脏病诊断标准的患者作为观察组,并收集同期正常妊娠患者57例作为对照组;将观察组患者根据纽约心脏协会(NHYA)心功能Ⅰ~Ⅳ级又分为四个亚组,根据28 d生存与否分为存活组(n=49)和死亡组(n=8)两个亚组。采用酶联免疫吸附法(ELISA)检测患者入院24 h内血浆s RAGE,同时进行B型利钠肽(BNP)水平测定。比较各组间患者s RAGE水平变化差异及分析s RAGE对妊娠期高血压性心脏病患者预后的判断价值。结果:观察组患者血浆s RAGE浓度显著高于对照组[(939.2±184.3)pg/ml vs(467.3±116.2)pg/ml,P0.05];观察组患者血浆s RAGE水平与NYHA心功能分级呈正相关关系(r=0.76,P0.001),随着心功能分级增加,血浆s RAGE浓度亦呈升高趋势(P0.05);观察组患者中死亡组的血浆s RAGE浓度明显高于生存组[(1647.6±249.7)pg/ml vs(776.9±146.2)pg/ml,P0.05];s RAGE和BNP诊断妊娠期高血压性心脏病的受试者操作特征曲线下面积分别为0.91和0.88,差异有统计学意义(P0.05)。结论:妊娠期高血压性心脏病患者血浆s RAGE水平升高,血浆s RAGE水平与心力衰竭严重程度相关,可作为患者预后的早期预测指标。
[Abstract]:Objective: To investigate the expression and clinical significance of soluble advanced glycosylation end product receptor (s RAGE) in hypertensive heart disease of pregnancy. Methods: 57 patients with pregnancy induced hypertensive heart disease were selected from 2013-06 to 2016-07 as an observation group, and 57 cases of normal pregnancy were collected as control. The patients in the observation group were divided into four subgroups according to the heart function of the New York Heart Association (NHYA) heart function class I ~ IV. According to the survival of 28 d, the survival group (n=49) and the death group (n=8) were divided into two subgroups. The plasma s RAGE was detected by enzyme linked immunosorbent assay (ELISA), and the B type natriuretic peptide (BNP) was measured in the patients' admission to the hospital, and the level of B type natriuretic peptide (BNP) was measured. The difference of s RAGE level and the evaluation value of s RAGE on the prognosis of hypertensive heart disease in pregnancy. Results: the plasma s RAGE concentration in the observation group was significantly higher than that of the control group [(939.2 + 184.3) pg/ml vs (467.3 + 116.2) pg/ml, P0.05], and the plasma s RAGE level in the observation group was positively correlated with the classification of cardiac function. 01), with the increase of cardiac function, the plasma s RAGE concentration also increased (P0.05), and the plasma s RAGE concentration in the death group was significantly higher than that in the survival group [(1647.6 + 249.7) pg/ml vs (776.9 + 146.2) pg/ml, P0.05]; s RAGE and BNP diagnosed high blood pressure heart disease under the operating characteristic curve of the subjects were 0.91, respectively. 0.88, the difference was statistically significant (P0.05). Conclusion: the level of plasma s RAGE in patients with hypertensive heart disease of pregnancy was elevated, and the level of s RAGE in plasma was associated with the severity of heart failure, which could be used as an early predictor of prognosis.

【作者单位】：甘肃省妇幼保健院急诊科;
【分类号】：R714.252

【相似文献】