甲羟孕酮片联合抗生素治疗子宫内膜炎的临床研究

发布时间：2018-04-30 02:17

本文选题：子宫内膜炎 + 甲羟孕酮　；参考：《中国临床药理学杂志》2017年20期

【摘要】：目的观察甲羟孕酮片联合甲硝唑和头孢曲松治疗子宫内膜炎的临床疗效及其对相关细胞因子的影响。方法将96例子宫内膜炎患者随机分为试验组与对照组,各48例。对照组给予注射用头孢曲松钠0.5 g,注射用甲硝唑25mg,每天1次,分别静脉滴注,连续治疗14 d。试验组在对照组的基础上给予醋酸甲羟孕酮片2 mg,每天1次,口服,连续服用21 d。2组均连续治疗2个月经周期。比较2组患者的临床疗效、临床症状消退时间、炎症因子变化及药物不良反应发生情况。结果治疗后,试验组和对照组的总有效率分别为95.83%(46/48例),81.25%(39/48例),差异有统计学意义(P0.05)。治疗后,试验组阴道出血、下腹坠痛、胀痛临床症状消退时间分别为(3.22±0.91),(5.43±2.16),(2.41±1.65)d,对照组分别为(5.18±1.35),(6.56±2.14),(5.26±1.87)d,差异均有统计学意义(均P0.05)。治疗后,试验组白细胞介素-2(IL-2)、白细胞介素-4(IL-4)及白细胞介素-10(IL~(-1)0)分别为(4.28±1.06),(8.06±1.03),(20.25±4.19)μg·L~(-1),对照组分别为(3.76±0.97),(9.04±0.91),(18.38±3.64)μg·L~(-1),差异均有统计学意义(均P0.05)。试验组出现头晕1例,困倦2例,药物不良反应发生率为6.25%(3/48例);对照组出现头晕3例,困倦3例,嗜睡4例,药物不良反应发生率为20.83%(10/48例),差异有统计学意义(P0.05)。结论头孢曲松、甲硝唑联合甲羟孕酮可迅速缓解子宫内膜炎患者各项临床症状,维持炎症因子的平衡,提高临床疗效,且药物不良反应轻微。
[Abstract]:Objective to observe the clinical effect of medroxyprogesterone tablets combined with metronidazole and ceftriaxone in the treatment of endometritis and its effect on cytokines. Methods 96 cases of endometritis were randomly divided into experimental group and control group, 48 cases in each group. The control group was given ceftriaxone sodium 0.5 g for injection and metronidazole 25 mg for injection once a day for 14 days. The experimental group was given medroxyprogesterone acetate 2 mg once a day on the basis of control group. The clinical efficacy, the time of clinical symptom regression, the changes of inflammatory factors and the occurrence of adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the test group and the control group were 95.83 / 46 / 48 / 81.25 / 39 / 48, respectively. The difference was statistically significant (P 0.05). After treatment, the clinical symptoms of vaginal bleeding, lower abdominal pain and flatulence in the experimental group were 3.22 卤0.91 and 5.41 卤1.65 days, respectively, and those in the control group were 5.18 卤1.35, 6.56 卤2.14 and 5.26 卤1.87 days, respectively. The difference was statistically significant (P 0.05). After treatment, the levels of Interleukin-2, IL-4 and IL-10 were 4.28 卤1.06 卤1.036 卤20.25 卤4.19 渭 g / L, respectively, in the experimental group and 3.76 卤0.97 卤0.97 卤0.91g / L, respectively, with statistical significance (P 0.05). There were 1 case of dizziness and 2 cases of sleepiness in the trial group, and the incidence of adverse drug reaction was 6.25% or 3 / 48 cases, while in the control group there were 3 cases of dizziness, 3 cases of sleepiness, 4 cases of drowsiness, and the incidence of adverse drug reaction was 20.833% 10 / 48 cases (P 0.05). Conclusion ceftriaxone, metronidazole and medroxyprogesterone can relieve the clinical symptoms of endometritis, maintain the balance of inflammatory factors, improve the clinical efficacy, and the adverse drug reaction is slight.
【作者单位】：启东市中医院妇产科;
【分类号】：R711.32

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