坤泰胶囊和激素替代治疗围绝经期综合征患者的有效性及安全性荟萃分析

发布时间：2018-04-30 05:16

本文选题：坤泰胶囊 + 激素替代疗法　；参考：《国际妇产科学杂志》2016年03期

【摘要】：目的:探讨坤泰胶囊和激素替代疗法治疗围绝经期综合征患者的有效性和安全性。方法:计算机检索Cochrane系统评价数据库、Pub Med、中国知网、维普数据库、万方数据库及其他相关数据库。收集2004年11月—2015年2月间国内公开发表的坤泰胶囊和激素替代疗法治疗围绝经期综合征患者的文献,筛选出随机对照临床试验,且治疗时间至少3个月。通过Meta分析比较2种疗法的有效性和安全性。有效性指标主要包括治疗3个月时的总有效率、Kupperman症状评分、血雌二醇(E2)水平、血卵泡刺激素(FSH)水平。安全性指标主要包括不良反应(胃肠道不适、乳房胀痛和阴道出血等)的发生率。结果:共纳入了15篇文献,包括1 243例患者。2组间总有效率及血FSH水平的变化值比较差异无统计学意义(P0.05);激素替代组患者Kupperman症状评分、血E2水平高于坤泰组,差异有统计学意义(P0.05);激素替代组患者的不良反应发生率高于坤泰组,差异有统计学意义(P0.05)。结论:坤泰胶囊能改善围绝经期综合征患者的临床症状,安全可靠。
[Abstract]:Objective: to investigate the efficacy and safety of Kuntai capsule and hormone replacement therapy in the treatment of perimenopausal syndrome. Methods: the evaluation database of Cochrane system was searched by computer, such as Pub Med, China knowledge net, Weip database, Wanfang database and other related databases. The literature of Kuntai capsule and hormone replacement therapy for perimenopausal syndrome patients published from November 2004 to February 2015 were collected and randomized controlled clinical trials were selected and the treatment time was at least 3 months. Meta analysis was used to compare the efficacy and safety of the two therapies. The effective indexes included Kupperman symptom score, serum estradiol E _ 2 (E _ 2) and serum follicle stimulating hormone (FSH) levels. Safety measures include the incidence of adverse reactions (gastrointestinal discomfort, breast pain, vaginal bleeding, etc.). Results: a total of 15 articles were included, including 1 243 patients with total effective rate and the change of blood FSH level. There was no significant difference in the changes of total effective rate and serum FSH level (P 0.05), the Kupperman symptom score of hormone replacement group was higher than that of Kuntai group, and the serum E 2 level was higher in hormone replacement group than that in Kuntai group. The incidence of adverse reactions in the hormone replacement group was higher than that in the Kuntai group, and the difference was statistically significant (P 0.05). Conclusion: Kuntai capsule can improve the clinical symptoms of patients with perimenopausal syndrome and is safe and reliable.
【作者单位】：天津市中心妇产科医院;天津市中医药大学;
【分类号】：R711.75

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