胎盘蛋白13联合胎盘生长因子早期筛查子痫前期的价值研究

发布时间：2018-04-30 17:06

本文选题：先兆子痫 + 妊娠蛋白质类　；参考：《中国全科医学》2017年S2期

【摘要】：目的探讨胎盘蛋白13(PP13)联合胎盘生长因子(PLGF)早期筛查子痫前期的价值。方法选取2014年1月—2015年12月三亚市妇幼保健院符合纳入标准的孕妇168例为研究对象。其中子痫前期84例(病例组),正常孕妇84例(对照组)。于妊娠期11~13周采用ELISA法分别检测血清PP13、PLGF水平,绘制PP13、PLGF及PP13联合PLGF早期筛查子痫前期的受试者工作特征曲线(ROC)曲线,并计算灵敏度、特异度、正确率。结果病例组血清PP13、PLGF水平低于对照组(P0.05)。PP13早期筛查子痫前期的灵敏度、特异度及正确率分别为83.3%、76.2%及79.8%,PLGF早期筛查子痫前期的灵敏度、特异度及正确率分别为82.1%、73.8%及78.0%,PP13联合PLGF早期筛查子痫前期的灵敏度、特异度及正确率分别为95.2%、94.0%及94.6%。结论 PP13联合PLGF对子痫前期具有较好的早期筛查效果。
[Abstract]:Objective to investigate the value of placental protein 13 (PP13) combined with placental growth factor (PLGF) in early screening of preeclampsia. Methods 168 pregnant women in Sanya Maternal and Child Health Hospital from January 2014 to December 2015 were selected. There were 84 cases of preeclampsia (case group) and 84 cases of normal pregnant women (control group). The serum PP13 PLGF levels were measured by ELISA method during 1113 weeks of gestation, and the operating characteristic curves of preeclampsia were plotted by PP13 PLGF and PP13 combined with PLGF, and the sensitivity, specificity and accuracy were calculated. Results the level of serum PP13 PLGF in the case group was lower than that in the control group. The specificity and accuracy were 83.3% and 79.8%, respectively, in the early screening of preeclampsia, and the sensitivity of PLGF in the early screening of preeclampsia was 79.8%. The specificity and accuracy were 82.1% and 78.0%, respectively. The sensitivity, specificity and accuracy of PP13 combined with PLGF in early screening of preeclampsia were 95.2% and 94.6%, respectively. Conclusion PP13 combined with PLGF has good early screening effect for preeclampsia.
【作者单位】：海南省三亚市妇幼保健院检验科;
【分类号】：R714.244

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