子宫内膜癌术后组织中Wilms基因、磷酸酶及张力蛋白同源蛋白和原癌基因C-MYC的表达及意义

发布时间：2018-04-30 18:27

本文选题：子宫内膜癌 + Wilms基因　；参考：《中国老年学杂志》2015年18期

【摘要】：目的检测子宫内膜癌术后组织中定位于X染色体上的Wilms基因(WTX)、磷酸酶及张力蛋白同源蛋白(PTEN)和原癌基因CMYC表达及其临床意义。方法 107例子宫内膜癌患者作为观察组,留取临床资料及术后的蜡块组织。78例复杂性增生的子宫内膜组织作为对照组,78例增生期子宫内膜组织作为正常对照组。三组均行免疫组化检测,检测WTX、PTEN和C-MYC的表达。结果三组中WTX、PTEN和C-MYC表达的阳性率差别均有统计学意义。观察组中WTX、PTEN和C-MYC表达的阳性率与肿瘤最大径、肌层浸润深度和Ki67的表达密切相关。相关性分析显示观察组中WTX、PTEN和C-MYC的表达均未见明显相关性。结论子宫内膜癌术后组织WTX、PTEN低表达、C-MYC高表达促进肿瘤的发生和进展。三者间无明显协同作用。
[Abstract]:Objective to detect the expression and clinical significance of Wilms gene, phosphatase and tension protein homologue protein (PTEN) and proto-oncogene CMYC in postoperative endometrial carcinoma tissues. Methods 107 cases of endometrial carcinoma were used as the observation group, and 78 cases of complicated hyperplasia endometrial tissue were taken as the control group and 78 cases of complicated hyperplasia endometrial tissue as the control group, 78 cases of proliferative endometrial tissue were taken as the normal control group. The expression of WTX C-MYC and PTEN were detected by immunohistochemistry in all three groups. Results the positive rates of WTX PTEN and C-MYC in the three groups were significantly different. The positive rates of WTX PTEN and C-MYC expression were closely related to the maximum diameter of tumor, the depth of myometrial invasion and the expression of Ki67 in the observation group. Correlation analysis showed that there was no significant correlation between the expression of WTX PTEN and C-MYC in the observation group. Conclusion the low expression of WTXT PTEN and the high expression of C MYC in endometrial carcinoma after operation promote the occurrence and progression of the tumor. There was no obvious synergy among them.
【作者单位】：承德护理职业学院临床2教研室;
【分类号】：R737.33

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