CD105、BMP9在绒癌组织中的表达及其临床病理意义

发布时间：2018-05-01 01:39

本文选题：绒癌 + 化疗　；参考：《现代妇产科进展》2017年09期

【摘要】：目的:研究绒癌化疗前后组织中CD105和BMP9的表达及其临床意义,为绒癌患者的个性化治疗和预后提供判断依据。方法:收集2010年1月至2015年12月于北京协和医院妇产科诊治的绒癌患者的石蜡组织标本41例,其中化疗前(初治组)标本8例,化疗后(化疗组)标本33例。免疫组化法检测CD105和BMP9在绒癌组织中的表达,分析CD105和BMP9表达与绒癌患者临床病理参数之间的关系。结果:初治组中CD105在细胞型、合体型滋养细胞中呈强阳性,在中间型滋养细胞中呈阴性或弱阳性表达;BMP9在中间型滋养细胞中呈强阳性表达,在细胞型、合体型滋养细胞中呈中等阳性表达。不同患者化疗前绒癌组织中CD105、BMP9表达具有相似性。化疗后,CD105、BMP9表达均减弱,表达水平与患者年龄、术前血清β-HCG、是否转移等无关,与患者复发呈正相关。细胞型和合体型滋养细胞中CD105和BMP9表达呈显著相关性(P0.05)。结论:CD105和BMP9在绒癌化疗后组织中表达下调,其表达水平可能与患者化疗耐药的产生和不良预后有关。
[Abstract]:Objective: To study the expression and clinical significance of CD105 and BMP9 in the tissues of choriocarcinoma before and after chemotherapy, and to provide the basis for judging the individualized treatment and prognosis of the patients with choriocarcinoma. Methods: 41 cases of paraffin tissue in the patients with choriocarcinoma from January 2010 to December 2015 were collected in the Department of gynecology and obstetrics and gynecology in Peking Union Medical College Hospital. After treatment (chemotherapy group) 33 cases. Immunohistochemical method was used to detect the expression of CD105 and BMP9 in the choriocarcinoma tissue and the relationship between the expression of CD105 and BMP9 and the clinicopathological parameters of the patients with choriocarcinoma. Results: in the primary treatment group, CD105 was strongly positive in the cell type, the syncytial trophoblastic cells and the negative or weakly positive expression in the medium type trophoblastic cells; BMP9 was in the primary treatment group. Middle type trophoblastic cells were strongly positive in the cell type and chimeric trophoblast cells. The expression of CD105 and BMP9 in the tumor tissues of different patients before chemotherapy was similar. After chemotherapy, the expression of CD105 and BMP9 decreased, the expression level was not related to the patient's age, the preoperative serum beta -HCG, the metastasis and so on, and the recurrence of Cheng Zhengxiang. There was a significant correlation between the expression of CD105 and BMP9 in the cell type and the chimeric trophoblast (P0.05). Conclusion: the expression of CD105 and BMP9 is down regulated in the tissues of choriocarcinoma after chemotherapy, and the expression level may be related to the production of chemotherapeutic drug resistance and the poor prognosis.

【作者单位】：中国医学科学院北京协和医学院北京协和医院妇产科;中国医学科学院北京协和医学院北京协和医院病理科;衡水市第二人民医院病理科;华北理工大学;
【基金】：国家自然科学基金资助项目(No:81672586)
【分类号】：R737.33

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