血叶酸、同型半胱氨酸及尿酸水平与妊娠期高血压疾病发病的相关性分析

发布时间：2018-05-03 03:40

本文选题：叶酸 + 同型半胱氨酸　；参考：《中国妇产科临床杂志》2017年04期

【摘要】：目的探讨血清叶酸、同型半胱氨酸(Hcy)和尿酸(UA)水平与妊娠期高血压疾病的关系。方法选择重度子痫前期患者135例及孕周匹配的正常妊娠孕妇135例作为对照组,采用化学发光法测定血清叶酸水平,全自动生化仪测定同型半胱氨酸、尿酸水平。结果妊娠28~41周~(+6),重度子痫前期组血清叶酸、同型半胱氨酸及尿酸水平分别为(8.66±5.63)μg/L、(10.85±5.52)μmol/L和(401.42±88.84)μmol/L,均高于对照组(11.33±6.76)μg/L、(9.22±4.19)μmol/L和(309.56±90.10)μmol/L(P0.05)。其中妊娠28~33周~(+6)重度子痫前期患者血清同型半胱氨酸、尿酸水平均高于对照组(P0.05);妊娠34~36周~(+6)重度子痫前期组血清叶酸水平低于对照组;妊娠37~41周~(+6)重度子痫前期组与对照组比较,仅血清尿酸水平高于对照组(P0.05)。结论血清叶酸、同型半胱氨酸和尿酸水平与重度子痫前期密切相关。
[Abstract]:Objective to investigate the relationship between serum folic acid, homocysteine homocysteine (HCH) and uric acid (UAA) levels and hypertensive disorder complicating pregnancy. Methods 135 patients with severe preeclampsia and 135 normal pregnant women with gestational week were selected as control group. Serum folic acid levels were measured by chemiluminescence assay and homocysteine and uric acid levels were measured by automatic biochemical instrument. Results the levels of serum folic acid, homocysteine and uric acid were 8.66 卤5.63 渭 g / L and 401.42 卤88.84 渭 mol / L respectively in the group of severe preeclampsia at the 41st week of gestation, which were higher than those in the control group (11.33 卤6.76) 渭 g / L 9.22 卤4.19 渭 mol/L and 309.56 卤90.10 渭 mol / L respectively. The levels of serum homocysteine and uric acid in patients with severe preeclampsia were significantly higher than those in control group (P 0.05), and the serum folic acid level in severe preeclampsia group was lower than that in control group at 346th week of gestation. The serum uric acid level in severe preeclampsia group was higher than that in control group (P 0.05). Conclusion the levels of serum folic acid, homocysteine and uric acid are closely related to severe preeclampsia.
【作者单位】：南京医科大学附属常州妇幼保健院产科;
【基金】：南京医科大学科技发展基金重点项目(2015NJMUZD080)
【分类号】：R714.246

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