妊娠期肝内胆汁淤积症患者外周血清抑制素A水平

发布时间：2018-05-03 10:12

本文选题：妊娠期肝内胆汁淤积症 + 抑制素A　；参考：《现代生物医学进展》2016年34期

【摘要】：目的:研究妊娠期肝内胆汁淤积症患者外周血清抑制素A水平及其与孕酮和雌二醇的相关性。方法:选择2014年1月~2015年9月在我院进行诊治的妊娠期肝内胆汁淤积症患者100例,根据病情程度分为轻度组和重度组,另选择20例健康孕妇为对照组。观察并比较三组血清抑制素A、孕酮和雌二醇水平,及血清抑制素A水平与孕酮和雌二醇的相关性。结果:与对照组相比,轻度组和重度组的血清抑制素A均明显升高(P0.05),且重度组的升高幅度明显大于轻度组(P0.05);与对照组相比,轻度组和重度组的孕酮水平阳性率和雌二醇水平阳性率明显高于正常对照组(P0.05),且重度组明显高于轻度组(P0.05);对照组血清抑制素A水平与孕酮(r=0.15,P0.05)和雌二醇(r=0.21,P0.05)水平不具有明显相关性,轻度组血清抑制素A水平与孕酮(r=0.36,P0.05)和雌二醇(r=0.38,P0.05)水平均呈明显正相关,重度组血清抑制素A水平与孕酮(r=0.57,P0.05)和雌二醇(r=0.59,P0.05)水平均呈明显正相关。结论:血清抑制素A、孕酮和雌二醇可能参与了妊娠肝内胆汁淤积症的发生、发展过程,联合检测血清抑制素A、孕酮和雌二醇有可能成为妊娠肝内胆汁淤积症诊断、分级的新分子标记物。
[Abstract]:Aim: to study the level of serum inhibin A and its correlation with progesterone and estradiol in patients with intrahepatic cholestasis of pregnancy. Methods: 100 patients with intrahepatic cholestasis of pregnancy who were treated in our hospital from January 2014 to September 2015 were divided into mild group and severe group according to their degree of illness and 20 healthy pregnant women were selected as control group. The levels of serum inhibin A, progesterone and estradiol, and the correlation between serum inhibin A and progesterone and estradiol were observed and compared among the three groups. Results: compared with the control group, serum inhibin A in the mild and severe groups was significantly higher than that in the control group, and that in the severe group was significantly higher than that in the mild group, and that in the severe group was significantly higher than that in the mild group, and that in the severe group was higher than that in the control group. The positive rates of progesterone and estradiol in the mild and severe groups were significantly higher than those in the normal control group (P 0.05), and the levels of serum inhibin A in the severe group were significantly higher than those in the mild group (P 0.05), while the serum inhibin A levels in the control group were not significantly correlated with the levels of progesterone, estradiol, estradiol or estradiol. The serum inhibin A level was positively correlated with the levels of progesterone (0.36) and estradiol (0.38) (P0.05) in the mild group, and the serum inhibin A level in the severe group was positively correlated with the levels of progesterone (0.57) and estradiol (0.59) (P0.05). Conclusion: serum inhibin A, progesterone and estradiol may be involved in the occurrence and development of intrahepatic cholestasis of pregnancy. The combined detection of serum inhibin A, progesterone and estradiol may become the diagnosis of intrahepatic cholestasis of pregnancy. A new molecular marker for classification.
【作者单位】：西北妇女儿童医院产科;
【分类号】：R714.255

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