胎盘组织缺氧诱导因子-1α和内皮素-1表达对糖尿病妊娠的影响

发布时间：2018-05-05 07:57

本文选题：胎盘组织 + HIF-α　；参考：《中国现代医学杂志》2016年20期

【摘要】：目的探究分析胎盘组织缺氧诱导因子-1α(HIF-1α)和内皮素-1(ET-1)表达对糖尿病妊娠的影响。方法分别选取糖尿病妊娠患者30例(糖尿病妊娠组)、妊娠期糖尿病患者30例(妊娠糖尿病组)以及正常孕妇30例(对照组)。采用免疫组织化学法SP法测定EF-1及HIF-1α蛋白的含量,比较并分析各组检测结果差异及其对糖尿病妊娠结局的影响。结果糖尿病妊娠患者胎盘组织EF-1及HIF-1α蛋白阳性表达率显著高于妊娠糖尿病患者及对照组(P0.05),糖尿病妊娠患者的产后出血、胎儿生长受限及妊娠高血压等并发症发生率(50.00%)显著高于妊娠糖尿病患者(30.00%)及对照组(10.00%),各组比较差异有统计学意义(P0.05)。结论胎盘组织EF-1及HIF-1α蛋白表达情况对糖尿病妊娠患者的妊娠结局具有不良影响,EF-1及HIF-1α蛋白阳性表达率越高,妊娠并发症发生率明显增加,胎盘损害越严重。
[Abstract]:Objective to investigate the effect of hypoxia inducible factor 1 伪 (HIF-1 伪) and endothelin 1 (et 1) expression on gestational diabetes mellitus (DM). Methods 30 cases of diabetic pregnancy (DM group), 30 cases of gestational diabetes mellitus (GDM group) and 30 normal pregnant women (control group) were selected. The contents of EF-1 and HIF-1 伪 protein were determined by SP immunohistochemical method. The difference of the results of each group and its effect on the pregnancy outcome of diabetes mellitus were compared and analyzed. Results the positive expression rate of EF-1 and HIF-1 伪 protein in placenta of patients with diabetes mellitus was significantly higher than that of patients with gestational diabetes mellitus and control group (P 0.05). The incidence of complications such as fetal growth restriction and pregnancy-induced hypertension was significantly higher than that of gestational diabetes mellitus (P 0.05). Conclusion the expression of EF-1 and HIF-1 伪 protein in placenta has adverse effect on the pregnancy outcome of diabetic pregnancy. The higher the positive expression rate of HIF-1 伪 and EF-1 protein is, the higher the incidence of pregnancy complications is and the more serious the placental damage is.
【作者单位】：山东省海阳市人民医院产科;
【分类号】：R714.256

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