S100A14与MMP-2在卵巢高分化黏液性癌中的表达及相关性研究

发布时间：2018-05-05 10:18

本文选题：SA + MMP-　；参考：《现代妇产科进展》2015年08期

【摘要】：目的:探讨S100A14与基质金属蛋白酶-2(MMP-2)在卵巢高分化黏液性癌中的表达情况及两者之间的相关性。方法:免疫组化法检测23例正常卵巢组织、21例交界性卵巢黏液性肿瘤、75例卵巢高分化黏液性癌中S100A14与MMP-2的表达。结果:S100A14和MMP-2表达量在正常卵巢组织、交界性卵巢黏液性肿瘤、卵巢癌中的表达均呈递增趋势,两两比较差异均有统计学意义(P0.05)。卵巢黏液性癌中,S100A14蛋白表达量与FIGO分期、有无淋巴结转移有关(P0.01);MMP-2蛋白表达量与FIGO分期有关(P0.01),而与淋巴结转移无关(P=0.342)。S100A14与MMP-2在卵巢黏液性癌中的表达呈正相关(P0.01)。结论:S100A14与MMP-2表达升高与卵巢黏液性癌的发生、进展、早期转移相关,有可能成为治疗卵巢癌的新靶点和评估预后的有力指标。
[Abstract]:Objective: to investigate the expression of S100A14 and matrix metalloproteinase-2 (MMP-2) in ovarian well differentiated mucinous carcinoma and the correlation between them. Methods: the expression of S100A14 and MMP-2 in 23 cases of normal ovarian tissues and 21 cases of borderline ovarian mucinous tumors were detected by immunohistochemical method in 75 cases of ovarian well-differentiated mucinous carcinoma. Results the expression of MMP-2 and S100A14 in normal ovarian tissues, borderline ovarian mucinous tumors and ovarian carcinomas showed an increasing trend, and the differences were statistically significant (P 0.05). The expression of S100A14 protein in ovarian mucinous carcinoma was correlated with FIGO stage, lymph node metastasis and FIGO stage, but not with P0.342S100A14 protein expression and MMP-2 expression in ovarian mucinous carcinoma. There was a positive correlation between the expression of P0.01and P0.01in ovarian mucinous carcinoma. Conclusion the increased expression of MMP-2 and S100A14 is associated with the occurrence, progression and early metastasis of ovarian mucinous carcinoma, which may be a new target for the treatment of ovarian cancer and a powerful index for evaluating prognosis.
【作者单位】：青岛大学附属医院东区妇科;
【分类号】：R737.31

【参考文献】