Srx与E-cadherin在宫颈鳞癌组织中的表达及临床意义

发布时间：2018-05-05 18:34

本文选题：硫氧还原蛋白 + E-钙黏蛋白　；参考：《免疫学杂志》2015年12期

【摘要】：目的探讨硫氧还原蛋白(Sulfiredoxin,Srx)与上皮细胞黏附分子E-钙黏蛋白(E-cadherin)在宫颈鳞癌组织中的表达及临床意义。方法采用免疫组织化学SABC法检测30例正常宫颈上皮组织(NC)、20例重度子宫颈上皮内瘤变(HSIL)及104例宫颈鳞状细胞癌(CSCC)组织中Srx和E-cadherin蛋白的表达情况,分析两者与宫颈鳞癌临床病理特征的关系及两者表达的相关性。结果 Srx在宫颈鳞癌组织中呈现高表达,而E-cadherin在鳞癌组织中表达明显降低,2蛋白阳性表达率在3组中比较差异具有统计学意义(P0.05),且Srx与E-cadherin蛋白表达呈负相关。宫颈鳞癌组织中Srx的表达与淋巴结转移、肿瘤浸润深度及有无脉管浸润有关(P0.05),而与患者年龄、临床分期、肿瘤大小及癌组织分化程度无关(P0.05)。E-cadherin的阳性表达率与肿瘤大小、组织分化程度及淋巴结转移关系密切(P0.05)。结论宫颈鳞癌组织中Srx的高表达与恶性临床病理特征密切相关,并与Ecadherin蛋白表达呈负相关,提示Srx可能通过调控EMT促进宫颈鳞癌进展。
[Abstract]:Objective to investigate the expression and clinical significance of Sulfiredoxin Srx) and E-cadherin (E-cadherin) in cervical squamous cell carcinoma (SCC). Methods Immunohistochemical SABC was used to detect the expression of Srx and E-cadherin in 30 cases of normal cervical epithelium and 20 cases of severe cervical intraepithelial neoplasia and 104 cases of cervical squamous cell carcinoma. To analyze the relationship between them and the clinicopathological features of cervical squamous cell carcinoma (SCC). Results there was a high expression of Srx in squamous cell carcinoma of cervix, while the positive rate of E-cadherin in squamous cell carcinoma was significantly lower than that in three groups (P 0.05), and the expression of Srx was negatively correlated with that of E-cadherin. The expression of Srx was related to lymph node metastasis, depth of tumor invasion and vascular invasion, but not to age, clinical stage, tumor size and tumor differentiation. Tissue differentiation and lymph node metastasis were closely related to P0.05. Conclusion the high expression of Srx is closely related to the clinicopathological features of cervical squamous cell carcinoma and negatively correlated with the expression of Ecadherin protein, suggesting that Srx may promote the progression of cervical squamous cell carcinoma by regulating EMT.
【作者单位】：重庆医科大学附属第一医院妇产科;
【分类号】：R737.33

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