中药复方对非肥胖型多囊卵巢综合征患者性激素的影响

发布时间：2018-05-06 02:28

本文选题：非肥胖型多囊卵巢综合征 + 肾虚肝郁　；参考：《中华中医药学刊》2015年02期

【摘要】：目的:观察补肾调肝中药复方对非肥胖型多囊卵巢综合征(PCOS)患者性激素的影响。方法:采用前瞻性单盲随机对照设计,选择肾虚肝郁型非肥胖型PCOS(BMI25)患者60例,随机分为治疗组30例,采用毓麟珠和柴胡舒肝散治疗3个月,每日1剂,早晚分服;对照组30例,选用二甲双胍片(格华止):1000 mg,每日2次,早晚随餐口服。对治疗前后性激素水平、月经周期,排卵率,妊娠率进行对比观察。结果:1.治疗3月后,两组患者LH/FSH较前水平均有降低,以治疗组降低明显,P0.05;2.治疗3月后,治疗组LH较前有明显降低,P0.05;对照组LH较前有降低,但无统计学差异;3.治疗3月后,两组月经周期、排卵率及妊娠率均有改善,治疗组疗效优于对照组,P0.05。结论:补肾调肝中药复方以及二甲双胍片均能改善非肥胖型多囊卵巢综合征患者月经周期,提高排卵率及妊娠率,可能是通过降低LH及LH/FSH起作用。
[Abstract]:Objective: to observe the effect of tonifying kidney and regulating liver compound on sex hormone in patients with non-obesity polycystic ovary syndrome (PCOS). Methods: a prospective, single blind randomized controlled design was used to select 60 patients with kidney deficiency and liver-depression type PCOSBMI25. They were randomly divided into treatment group (n = 30) and control group (n = 30) treated with Yulin Zhu and Chaihu Shugan Powder for 3 months, 1 dose per day, in the morning and evening, and 30 patients in the control group. Take metformin tablet twice a day, morning and evening with meal. Sex hormone level, menstrual cycle, ovulation rate and pregnancy rate before and after treatment were observed. The result is 1: 1. After 3 months of treatment, the LH/FSH level in both groups was lower than that in the former group, especially in the treatment group. After 3 months of treatment, LH in the treatment group was significantly lower than that in the former group (P 0.05), while in the control group it was lower than that in the former group, but there was no statistical difference between the two groups. After 3 months of treatment, the menstrual cycle, ovulation rate and pregnancy rate of the two groups were improved, and the curative effect of the treatment group was better than that of the control group (P 0.05). Conclusion: both prescription of tonifying kidney and regulating liver and metformin tablets can improve menstrual cycle, increase ovulation rate and pregnancy rate in patients with non-obese polycystic ovary syndrome, which may be due to the decrease of LH and LH/FSH.
【作者单位】：浙江省中西医结合医院;杭州师范大学;黑龙江中医药大学附属第一医院;
【基金】：浙江省中医药管理局青年基金项目(ZQ2010012)
【分类号】：R711.75

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