层流洁净手术室环境对体外受精-胚胎移植结局的影响

发布时间：2018-05-07 13:43

本文选题：层流洁净手术室 + 体外受精　；参考：《中国计划生育学杂志》2016年11期

【摘要】：目的:对比本院生殖中心层流洁净手术室改进前后体外受精-胚胎移植结局的差异,以期为临床工作提供理论依据。方法:层流洁净手术室改进前3267个生殖周期为A组,改进后的3370个生殖周期为B组。按本中心常规辅助生殖方案进行体外受精和胚胎移植,分析两组的年龄、不孕年限、受精率、2PN卵裂率、优质胚胎率、种植率、临床妊娠率等指标的差异。结果:A组受精率、卵裂率、优质胚胎率、种植率、临床妊娠率与B组比较均有统计学意义(P0.05),两组多胎率和流产率差异无统计学意义(P0.05)。校正年龄与不孕年限的影响后,B组受精率、卵裂率、优质胚胎率、种植率、临床妊娠率和多胎率仍显著高于A组(P0.05),流产率低于A组(P0.05)。结论:层流洁净手术室的建立对于提高临床妊娠结局具有重要意义,值得在生殖中心和医院中推广。
[Abstract]:Objective: to compare the outcome of in vitro fertilization and embryo transfer before and after the improvement of laminar flow clean operating room in reproductive center of our hospital in order to provide theoretical basis for clinical work. Methods: 3267 reproductive cycles of laminar clean operating room were divided into group A and 3370 reproductive cycles were treated as group B. In vitro fertilization and embryo transfer were carried out according to the routine assisted reproductive program of our center. The differences of age, length of infertility, fertilization rate and 2PN cleavage rate, high quality embryo rate, implantation rate and clinical pregnancy rate were analyzed between the two groups. Results the fertilization rate, cleavage rate, high quality embryo rate, implantation rate and clinical pregnancy rate in group A were significantly higher than those in group B (P 0.05). There was no significant difference in the rate of multiple births and abortion between the two groups (P 0.05). The fertilization rate, cleavage rate, high quality embryo rate, implantation rate, clinical pregnancy rate and multiple pregnancy rate in group B were still significantly higher than those in group A (P 0.05) and abortion rate was lower than group A (P 0.05). Conclusion: the establishment of laminar flow clean operating room is of great significance to improve the clinical pregnancy outcome and is worth popularizing in reproductive center and hospital.
【作者单位】：广东省妇幼保健院生殖健康与不孕症科;
【基金】：广州市科技创新委员会项目(201510010290)
【分类号】：R714.8

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