双刺激方案在低卵泡输出率患者中的应用价值

发布时间：2018-05-08 03:29

本文选题：双刺激 + 体外受精-胚胎移植　；参考：《实用医学杂志》2017年20期

【摘要】：目的探讨双刺激方案在低卵泡输出率(FORT)患者中的临床应用价值。方法回顾性分析我院行IVF/ICSI-ET助孕226例低FORT患者资料,67例卵泡期促排卵后继续行黄体期促排卵(双刺激组);159例选择新鲜周期胚胎移植或全胚胎冷冻(低FORT组),对其中60例新鲜及冷冻周期移植未妊娠或妊娠失败的患者行再次常规方案促排卵(对照组),比较各组的临床结局。结果双刺激组中黄体期促排卵的获卵数、MⅡ卵数、2PN受精数、优质胚胎数均显著高于同一周期卵泡期促排卵(P0.05)。双刺激组的总获卵数、MⅡ卵数、2PN受精数、优质胚胎数、冷冻胚胎数及临床妊娠率均显著高于低FORT组(P0.05),流产率显著低于低FORT组(P0.05),但与对照组间差异无显著性。结论双刺激方案能在短时间内累积更多的可利用胚胎,在FET周期获得较满意的临床结局,是低FORT患者有效的补充治疗方式。
[Abstract]:Objective to evaluate the clinical value of double stimulation regimen in patients with low follicle output rate (FORT). Methods A retrospective analysis was made on the data of 226 patients with IVF/ICSI-ET assisted pregnancy with low FORT. 67 cases of follicular phase ovulation and luteal phase ovulatory stimulation were performed. In the double stimulation group, 159 cases were selected for fresh cycle embryo transfer or whole embryo freezing (low FORT group), and the results were compared with those in the low FORT group. Sixty cases of fresh and cryopreserved recipients without or failing in pregnancy were treated with second routine protocol to promote ovulation (control group) and the clinical outcomes of each group were compared. Results in the double stimulation group, the number of oocytes obtained in luteal phase and the number of 2 PN fertilized eggs were significantly higher than those in the follicular stage of the same cycle (P 0.05). The total number of eggs obtained in the double stimulation group was significantly higher than that in the low FORT group (P 0.05), and the abortion rate was significantly lower than that in the low FORT group (P 0.05), but there was no significant difference between the two groups. Conclusion the double stimulation scheme can accumulate more available embryos in a short period of time and obtain satisfactory clinical outcome in FET cycle. It is an effective supplementary therapy for low FORT patients.
【作者单位】：安徽医科大学解放军临床学院生殖医学中心;中国人民解放军第105医院生殖医学中心;
【基金】：安徽省科技攻关项目(编号:1604a0802095) 南京军区医学科技创新重点项目(编号:ZD14)
【分类号】：R714.8

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