地屈孕酮预处理可以增加拮抗剂方案中卵泡均匀性

发布时间：2018-05-09 13:44

  本文选题：体外受精 + 拮抗剂方案　； 参考：《生殖医学杂志》2013年10期

【摘要】：目的探讨卵巢低反应者行体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)助孕治疗时,在拮抗剂方案中地屈孕酮预处理对卵泡均匀性的影响。方法分析促排卵前一月经周期黄体中期行地屈孕酮预处理组(A组)73例和未行预处理对照组(B组)118例患者,对其月经第2天(D2)卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_2),促性腺激素(Gn)天数、用量,拮抗剂天数、用量,注射人绒毛膜促性腺激素(HCG)日E_2、LH、孕激素(P)、子宫内膜厚度、卵泡不同步率(将最大卵泡与次大卵泡平均直径相差≥3 mm则视为不同步)、回收卵数、受精率、优胚率、着床率、临床妊娠率、继续妊娠率等进行对比观察。结果与B组相比,A组D2 FSH下降[(7.75±4.03)vs.(9.28±4.08)IU/L,P=0.012];A组HCG日E_2增加L(4,593.39±2,334.35)vs.(3,784.94±2,065.36)pmol/L,P=0.013],回收卵数增加[(5.29±3.03)vs.(4.31±3.18)枚,P=0.036];A组Gn启动第7日卵泡不均匀率(16.44%vs.31.36%,P=0.022)及HCG日卵泡不均匀率(23.29%vs.37.29%,P=0.044)均下降。结论地屈孕酮预处理可促进卵泡发育的均匀性。
[Abstract]:Objective to investigate the effect of diproprogesterone preconditioning on follicular homogeneity during IVF / ICSI-ETT in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI-ETT) in patients with low ovarian response. Methods 73 patients in group A and 118 patients in group B were treated with Diflexiprogesterone in the middle luteal phase of the first cycle before ovulation. On the 2nd day of menstruation, the days of follicle stimulating hormone (FSHN), luteinizing hormone (LHH), estradiol (E2N), gonadotropin (Gn), dosage, days of antagonist, dosage, E2LHH, progesterone, thickness of endometrium, and the day of injection of human chorionic gonadotropin (HCG) were studied. The average diameter difference between the largest follicle and the second big follicle was considered to be out of sync. The number of eggs recovered, fertilization rate, embryo rate, implantation rate, clinical pregnancy rate and continuous pregnancy rate were compared and observed. 缁撴灉涓嶣缁勭浉姣，

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