760名女性生殖道高危型人乳头瘤病毒感染自然转归规律及影响因素

发布时间：2018-05-10 11:08

  本文选题：高危型人乳头瘤病毒 + 自然清除　； 参考：《中国医学科学院学报》2015年05期

【摘要】：目的了解西安地区女性生殖道高危型人乳头瘤病毒(HR-HPV)感染自然转归规律及影响因素。方法采用HPV-DNA分型检测技术对760例初次感染HR-HPV的西安地区女性进行随访检测,必要时行液基细胞学和/或阴道镜检查。结果 760名女性生殖道HR-HPV自然清除率为71.58%,中位时间8.10个月;持续感染率为22.63%,中位时间17.23个月;进展率为5.79%,中位时间29.34个月。50岁以上年龄组自然清除率(P=0.000)、持续感染率(P=0.000)和进展率(P=0.040)与其他年龄组相比差异有统计学意义。多重感染组持续感染率明显低于单一感染组(P=0.010),但其中位时间明显长于单一感染组(P=0.018)。易进展型别为HPV-16、HPV-33、HPV-58、HPV-18、HPV-52、HPV-68,其中HPV-16在宫颈上皮内瘤变(CIN)Ⅲ/宫颈癌(CC)中最常见,占85.00%。结论多数HR-HPV感染在2年内被清除,仅少数进展为CIN/CC。50岁以上女性自然清除率低,持续感染率和进展率高,多重感染影响病毒持续,HPV-16是本地区最常见的致癌株。
[Abstract]:Objective to investigate the natural outcome and influencing factors of high risk human papillomavirus (HR-HPVV) infection in female genital tract in Xi'an. Methods HPV-DNA typing technique was used to detect 760 women in Xi'an area who were first infected with HR-HPV, and liquid-based cytology and / or colposcopy were performed when necessary. Results the natural clearance rate of HR-HPV in 760 female genital tract was 71.58, the median time was 8.10 months, the persistent infection rate was 22.633.The median time was 17.23 months. The rate of progression was 5.79, the median time was 29.34 months. The natural clearance rate was 0.000, the rate of persistent infection was 0.000) and the rate of progression was 0.040), which was significantly different from that of other age groups. The persistent infection rate in the multiple infection group was significantly lower than that in the single infection group, but the site time was significantly longer than that in the single infection group. The easily progressive type was HPV-16, HPV-33, HPV-58, HPV-18, HPV-52, HPV-68, in which HPV-16 was the most common type in cervical intraepithelial neoplasia (cin 鈪，

本文编号：1869056