PIGF、sVEGFR-1、NO联合PI对高危孕妇发生子痫前期的预测

发布时间：2018-05-10 12:36

本文选题：子痫前期 + 血清胎盘生长因子　；参考：《中山大学学报(医学科学版)》2015年06期

【摘要】：【目的】探讨血清胎盘生长因子(PIGF)、可溶性血管内皮生长因子受体-1(s VEGFR-1)、一氧化氮(NO)浓度联合子宫动脉搏动指数(PI)在高危孕妇中预测子痫前期发生的价值。【方法】收集162例具有子痫前期高危因素孕妇妊娠22~26周时的血清标本,应用酶联免疫吸附试验(ELISA)检测PIGF及s VEGFR-1浓度,比色法检测NO浓度,同期行子宫动脉多普勒超声检查测定PI值。【结果】134例孕妇发生子痫前期(子痫前期组),128例孕妇血压始终维持正常(血压正常组)。2子痫前期组孕妇血清中PIGF、s VEGFR-1、NO水平及PI分别为(264±116)pg/m L、(4823±1562)pg/m L、(57±28)μmol/L、2.7±0.1;血压正常组分别为(418±130)pg/m L、(1102±158)pg/m L、(107±28)μmol/L、2.2±0.2。两组比较,差异均有统计学意义(P0.001)。3单一参数预测子痫前期的敏感度和特异度Pl GF为78.0%和80.7%(切割值为286.3 pg/m L时),s VEGFR-1为81.2%和83.5%(切割值为2 005.0 pg/m L时),NO为75.2%和80.0%(切割值为50.9μmol/L时),PI为79.6%和86.2%(切割值为2.31时)。联合4项参数阳性值预测子痫前期的敏感度和特异度为92.7%和95.6%,均高于单一参数(P0.001)。血清PIGF、s VEGFR-1、NO的浓度与母亲的妊娠结局显著关联(P0.001)。【结论】血清PIGF、s VEGFR-1、NO浓度联合PI在孕22~26周的高危孕妇中预测子痫前期的发生有较好的临床价值。
[Abstract]:[objective] to study the value of serum placental growth factor (PIGFN), soluble vascular endothelial growth factor receptor (VEGFR-1), nitric oxide (no) and uterine artery pulsatile index (Pi) in predicting preeclampsia in high-risk pregnant women. The serum samples of 162 pregnant women with high risk factors of preeclampsia at 2226 weeks of pregnancy were collected. Enzyme linked immunosorbent assay (Elisa) was used to detect the concentration of PIGF and s VEGFR-1, and the concentration of no was detected by colorimetry. [results] 134 pregnant women developed preeclampsia (128 pregnant women in preeclampsia group) and their blood pressure remained normal (PIGFs VEGFR-1no in serum of preeclampsia group of normal blood pressure group. 2. 2 preeclampsia group) The levels of Pi and Pi were 484 卤116)pg/m / L 4823 卤1562)pg/m / L = 57 卤28 渭 mol / L / L = 2.7 卤0.1, respectively, and those of normal blood pressure group were 1 102 卤158)pg/m / L ~ (107 卤28) 渭 mol / L ~ (2. 2 卤0. 2) 渭 mol / L ~ (2) 卤0. 2, respectively. The two groups were compared, There were significant differences in the sensitivity and specificity of P0.001n.3 single parameter in predicting preeclampsia. The sensitivity and specificity of Pl GF were 78.0% and 80.7% (when the cutting value was 286.3 pg/m / L, the VEGFR-1 was 81.2% and 83.5% respectively) (when the cutting value was 2 005.0 pg/m / L, the no was 75.2% and 80.0% (the cutting value was 50.9 渭 mol/L). 79.6% and 86.2% (cutting value 2.31%). The sensitivity and specificity in predicting preeclampsia with positive values of 4 parameters were 92.7% and 95.6%, respectively, which were higher than those of single parameter (P 0.001). There was a significant correlation between the concentration of serum PIGFFN VEGFR-1no and the pregnancy outcome of the mother. [conclusion] Serum PIGFFs VEGFR-1no concentration combined with Pi has a good clinical value in predicting preeclampsia in high risk pregnant women at 2226 weeks of gestation.
【作者单位】：中山大学附属第三医院产科;
【基金】：广东省科技厅社会发展项目(2011B031800)
【分类号】：R714.244

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