10年宫颈腺癌住院患者发病趋势及临床特点分析

发布时间：2018-05-10 19:40

  本文选题：宫颈腺癌 + 发病趋势　； 参考：《实用妇产科杂志》2017年11期

【摘要】：目的:探讨10年来宫颈腺癌住院患者发病趋势及临床特点。方法:2006年1月至2016年5月北京大学第一医院确诊为宫颈腺癌并符合研究标准的住院患者99例,回顾性分析诊断途径、肿瘤分期及细胞学、病毒筛查情况等临床特点。结果:(1)近10年腺癌的发病比例呈现上升的趋势,不同时期宫颈腺癌临床分期差异有统计学意义(P0.05)。(2)宫颈腺癌排在前3位的临床症状为阴道不规则流血、性生活后阴道流血、阴道分泌物异常,分别占37.37%(37例)、34.34%(34例)和8.08%(8例)。症状就诊组与体检就诊组比较后发现,宫颈腺癌临床分期、肿块直径、肌层浸润程度差异有统计学意义(P0.05),而分化程度、病理类型、淋巴结转移、手术切缘等比较差异无统计学意义(P0.05)。(3)宫颈腺癌细胞学筛查仍以鳞状细胞改变为主(42.19%),HPV检测中最常见型别为HPV18,占36.21%(21/58),17例(29.31%)HPV检测阴性。HPV阴性患者与阳性患者比较,宫颈腺癌肿块直径、肌层浸润及脉管癌栓差异有统计学意义(P0.05),而发病年龄、病理类型、分化程度、临床分期、手术切缘及淋巴结转移比较差异无统计学意义(P0.05)。结论:宫颈腺癌发生率逐年上升,但部分宫颈腺癌患者在筛查中表现为细胞学及HPV阴性,容易被漏诊,应提高对宫颈腺癌患者筛查的关注。
[Abstract]:Objective: to investigate the incidence trend and clinical characteristics of cervical adenocarcinoma inpatients in recent 10 years. Methods: from January 2006 to May 2016, 99 patients with cervical adenocarcinoma diagnosed in the first Hospital of Peking University who met the research criteria were retrospectively analyzed for the clinical features of diagnosis, tumor staging, cytology, virus screening and so on. Results (1) the incidence rate of adenocarcinoma of cervix increased in the last 10 years, and there were significant differences in clinical stages of cervical adenocarcinoma in different periods (P 0.05). 2) the first three clinical symptoms of cervical adenocarcinoma were irregular vaginal bleeding and vaginal bleeding after sexual life. The vaginal discharge was abnormal in 37.37 cases (34.34 cases) and 8.08 cases in 8 cases. The clinical stage of cervical adenocarcinoma, the diameter of mass and the degree of myometrium infiltration were significantly different between the symptom group and the physical examination group (P 0.05), but the differentiation degree, pathological type, lymph node metastasis were significantly different. There was no statistically significant difference in surgical margin between the two groups. (P0.05) the cytological screening of cervical adenocarcinoma was still dominated by squamous cell changes. The most common type of HPV detection was HPV18, accounting for 36.21% of 21% of HPV18, accounting for 17 cases of HPV-negative or HPV-negative in 17 patients with negative or negative HPV testing. The diameter of cervical adenocarcinoma masses was higher than that of the controls. There were significant differences in myometrial invasion and vascular tumor thrombus (P 0.05), but there was no significant difference in age, pathological type, differentiation, clinical stage, surgical margin and lymph node metastasis. Conclusion: the incidence of cervical adenocarcinoma is increasing year by year, but some of the cervical adenocarcinoma patients are cytological and HPV negative, which is easy to be missed, so we should pay more attention to the screening of cervical adenocarcinoma patients.
【作者单位】： 北京大学第一医院;
【分类号】：R737.33
，

本文编号：1870610