598例妊娠中晚期胎儿超声异常与染色体异常的关系

发布时间：2018-05-11 05:42

本文选题：胎儿 + 超声异常　；参考：《实用妇产科杂志》2015年02期

【摘要】：目的:探讨妊娠中、晚期胎儿超声异常时染色体异常情况,以指导脐血穿刺的选择。方法:对我院胎儿超声异常的598例妊娠中、晚期孕妇取脐血进行染色体检查,分析胎儿超声结构异常及超声软指标异常的异常染色体检出率及异常染色体分类。结果:598例孕妇中,染色体异常61例,检出率10.20%,其中三体儿42例,占染色体异常的68.85%;超声结构异常胎儿染色体异常检出率明显高于超声软指标异常胎儿(P0.05);2项、3项及以上超声软指标异常染色体异常检出率明显高于单项软指标异常胎儿(P0.05);鼻骨缺失染色体异常检出率41.67%,单脐动脉染色体异常检出率12.24%;超声异常合并高龄孕妇组染色体异常检出率明显高于合并低孕龄组(P0.05);超声异常合并羊水过多组异常染色体检出率明显高于合并羊水正常组(P0.05)。结论:当有胎儿超声结构异常、超声软指标鼻骨缺失、两项及以上软指标异常、超声软指标异常合并高龄或羊水过多的情况时,染色体异常发生率明显增加,建议行脐血管穿刺染色体检查。
[Abstract]:Objective: To explore the abnormal situation of chromosomes during abnormal fetal ultrasound in pregnancy, in order to guide the selection of umbilical cord blood puncture. Methods: in 598 pregnant women with abnormal fetal ultrasound in our hospital, the late pregnant women take the umbilical blood for chromosome examination, and analyze the abnormal examination rate and abnormal chromosomes of abnormal fetal ultrasonic structure and abnormal ultrasound. Results: among the 598 pregnant women, there were 61 cases of chromosomal abnormalities, the detection rate was 10.20%, of which 42 cases were trisomy, accounting for 68.85% of chromosomal abnormalities, and the abnormal detection rates of abnormal fetal chromosomes were significantly higher than those of abnormal ultrasonic soft indexes (P0.05); 2, 3 or more soft indexes of ultrasonic soft indexes were significantly higher than those of single soft fingers. Abnormal fetal (P0.05), abnormal detection rate of chromosome abnormality of nasal bone was 41.67%, chromosome abnormality detection rate of single umbilical artery was 12.24%, and the rate of chromosome abnormality was significantly higher than that of combined low gestational age group (P0.05), and abnormal ultrasonic examination of abnormal amniotic fluid group with abnormal amniotic fluid was significantly higher than that of normal amniotic fluid group (P0.0 5) conclusion: when there is abnormal ultrasonic structure of fetus, missing of nasal bone and abnormal soft indexes of two and above, the abnormal incidence of chromosomes is obviously increased when ultrasonic soft indexes are abnormal with age or amniotic fluid.

【作者单位】：上海交通大学附属第六人民医院;
【分类号】：R714.5

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