江苏地区医院就诊的女性患者HPV感染情况及型别特征—附6003例分析报告

发布时间：2018-05-11 11:35

本文选题：人乳头瘤状病毒(HPV) + HPV基因分型　；参考：《中国妇产科临床杂志》2015年05期

【摘要】：目的探讨江苏地区女性宫颈疾病HPV基因检测的感染情况及流行分布。方法用Luminex200流式荧光杂交技术对来自江苏省13个地区的500多家医院门诊就诊的6 003例患者进行了HPV基因分型检测,研究HPV在女性人群中的感染率,基因型别和地区分布的特点。结果 6 003例标本中HPV阳性例数1 842例,总感染率为30.68%,苏北、苏中、苏南感染率差异无统计学意义(P0.05);HPV单一亚型感染率为65.48%,高于多重亚型感染的情况,差异有统计学意义(P0.05);HPV高危亚型感染最多的亚型是16、52、58、53型;苏北地区50岁以上人群的阳性率高于其他年龄层,差异有统计学意义(P0.05);苏中地区与苏北地区,各年龄层人群的HPV感染率差异均无统计学意义(P0.05)。结论江苏地区HPV感染率在中国大陆地区属于较高状态,多重亚型感染的比例也相对较高,HPV感染最多的亚型中16和58属于高危型HPV病毒中致癌活性最高的亚型之一。这些信息也都提示江苏地区宫颈癌的防治工作颇为严峻。同时,在江苏地区年龄17~35岁和大于50岁都属于HPV感染的高峰年龄,尤其是苏北地区年龄大于50岁人群。加强对这些人群的宫颈病变的检查对于宫颈癌的早期诊断和治疗有积极的意义。
[Abstract]:Objective to investigate the prevalence and prevalence of HPV gene detection in women with cervical diseases in Jiangsu province. Methods HPV genotyping was performed in 6 003 outpatients from more than 500 hospitals in 13 regions of Jiangsu Province by Luminex200 flow fluorescence hybridization. The infection rate, genotypic and regional distribution of HPV in female population were studied. Results among 6 003 specimens, 1 842 cases were positive for HPV, the total infection rate was 30.68. There was no significant difference in infection rate between north Jiangsu, middle Jiangsu and southern Jiangsu. The infection rate of single subtype of HPV was 65.48, which was higher than that of multiple subtype infection. The most high risk subtypes of P0.05HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-HPV-@@ There was no significant difference in HPV infection rate among different age groups (P 0.05). Conclusion the infection rate of HPV in Jiangsu is high in mainland China, and 16 and 58 of the most frequent subtypes of HPV infection belong to one of the most carcinogenic subtypes of high risk HPV virus. These information also suggest that the prevention and treatment of cervical cancer in Jiangsu is rather severe. At the same time, the age of 1735 years old and over 50 years old belong to the peak age of HPV infection in Jiangsu area, especially in north Jiangsu area. Strengthening the detection of cervical lesions in these populations has positive significance for early diagnosis and treatment of cervical cancer.
【作者单位】：江苏省南京金域医学检验所;
【分类号】：R737.33

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