乳杆菌制剂及恢复阴道微生态平衡在细菌性阴道病治疗中的应用研究

发布时间：2018-05-11 13:24

本文选题：细菌性阴道病 + 乳杆菌　；参考：《现代生物医学进展》2016年36期

【摘要】：目的:研究乳杆菌制剂在细菌性阴道病(bacterial vaginosis,BV)治疗中的作用及其恢复阴道微生态平衡预防BV复发的价值,探讨治疗BV时应用乳杆菌制剂的重要作用及恢复阴道微生态平衡的时间。方法:选取BV患者150例,随机分为3组,A组单一给予抗生素治疗;B组抗生素治疗后补充乳杆菌制剂1疗程;C组抗生素治疗后补充乳杆菌制剂,每周评估阴道微生态,直至重建阴道微生态平衡后停药;三组停药后均随访3个月。对比分析3种治疗方案的临床疗效及复发情况。结果:3组治愈率均较高,为91.30%-95.73%,无统计学差异(P0.05);各随访阶段累计复发率,B组和C组明显低于A组,差异有统计学意义(P0.05);C组与B组相比,累计复发率更低;首发BV、有BV史BV、复发BV患者治疗后重建阴道微生态平衡所需疗程分别为3.53、5.18、7.43,有统计学差异(P0.01)。结论:单独采用抗生素治疗BV复发率高,联合乳杆菌制剂治疗后可以有效减低复发率,而适当地延长乳杆菌治疗时间彻底恢复阴道微生态平衡将显著降低BV复发率;BV患者既往发生BV次数与重建阴道微生态平衡所需时间呈正相关;因此,应重视每一次BV治疗。
[Abstract]:Objective: to study the role of lactobacillus preparation in the treatment of bacterial vaginosis (BV) and the value of restoring vaginal microecological balance to prevent the recurrence of BV, and to explore the important role of Lactobacillus preparation in the treatment of BV and the time to restore the vaginal microecological balance. Methods: one hundred and fifty patients with BV were randomly divided into three groups: group A was treated with antibiotics alone and group B was given lactobacillus after antibiotic treatment for one course of treatment and group C was supplemented with Lactobacillus after antibiotic treatment. The vaginal microecology was evaluated weekly. The three groups were followed up for 3 months. The clinical efficacy and recurrence of three treatment schemes were compared and analyzed. Results the cure rate of the three groups was higher (91.30-95.73C), there was no statistical difference (P0.05), the cumulative recurrence rate of group B and group C was significantly lower than that of group A (P 0.05), and the cumulative recurrence rate of group C was lower than that of group B (P 0.05), and that of group C (P 0.05) was lower than that of group B (P < 0.05), and the cumulative recurrence rate of group C was significantly lower than that of group B. The first course of treatment for patients with recurrent BV was 3.53 卤5.187.43, and there was significant difference between the two groups (P < 0.01). The first BV had a history of BV, and the course of treatment for patients with recurrent BV was 3.53 卤5.187.43, respectively. Conclusion: the recurrence rate of BV is high by using antibiotics alone, and the recurrence rate can be reduced effectively after treatment with lactobacillus preparation. However, prolonging the treatment time of Lactobacillus and restoring the vaginal microecological balance could significantly reduce the recurrence rate of BV and the time needed to reconstruct the vaginal microecological balance in BV patients. Therefore, we should pay attention to each BV treatment.
【作者单位】：内蒙古医科大学附属医院妇产科;
【基金】：国家自然科学青年基金项目(81202730)
【分类号】：R711.31

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