坤泰胶囊在卵巢储备功能降低的不孕症患者中的应用

发布时间：2018-05-11 14:59

本文选题：坤泰胶囊 + 芬吗通　；参考：《中成药》2017年06期

【摘要】：目的探讨中药坤泰胶囊在卵巢储备功能降低的不孕症患者中的应用。方法选择自2013年10月31日至2015年10月31日在我院生殖医学科门诊就诊的不孕症患者中,根据入选标准以及用药记录,分为3组,芬吗通组55例,月经第3天测定卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E_2)、基础窦卵泡数(AFC)、抗苗勒管激素(AMH),开始口服芬吗通1片qd,连用3个月,月经第3天再次测定FSH、LH、E_2、AFC、AMH;坤泰组(芬吗通+坤泰组)58例,月经第3天测定FSH、LH、E_2、AFC、AMH,开始口服芬吗通1片qd加坤泰胶囊4粒tid,连用3个月,月经第3天再次测定FSH、LH、E_2、AFC、AMH;空白对照组(未用药,自然周期试孕)60例,月经第3天测定FSH、LH、E_2、AFC、AMH,3个月后再次测量FSH、LH、E_2、AFC、AMH;比较前后两次FSH、LH、FSH/LH、E_2、AFC、AMH水平。结果组内比较:芬吗通组FSH、LH降低,FSH/LH升高,有统计学意义(P0.05),AMH、AFC呈升高趋势,无统计学意义(P0.05);坤泰组FSH、LH降低、FSH/LH升高,有统计学意义(P0.05),AMH、AFC呈升高趋势,无统计学意义(P0.05);空白对照组FSH、LH、FSH/LH升高,有统计学意义(P0.05),AFC、AMH降低,有统计学意义(P0.05)。组间比较:空白对照组FSH、LH、FSH/LH升高,有统计学意义(P0.05);AFC、AMH降低,有统计学意义(P0.05);芬吗通组、坤泰组FSH、LH、FSH/LH、AFC、AMH组间比较无统计学意义(P0.05)。结论坤泰胶囊能够改善卵巢储备功能,并有助于妊娠。
[Abstract]:Objective to explore the application of Kuntai capsule in infertility with decreased ovarian reserve function. Methods from October 31, 2013 to October 31, 2015, the infertile patients in our department of reproductive medicine were divided into 3 groups according to the selection criteria and medication records. On the 3rd day of menstruation, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E _ 2), basic antral follicle count (AFC), anti-mullerian hormone (AMH) were measured. On the third day of menstruation, the FSHLHHG E2FACAMH was determined again; the Kuntai group (Fenmotonkuntai group, 58 cases), the third day of menstruation, the FSHLHHN2AFCU AMH was measured, and the 4 tids of FSHLHX 1 tablet QD and kuntai capsule were taken orally at the beginning of the 3rd day of menstruation, and on the 3rd day of menstruation, the AFCAMH of FSHLHX E2 was determined again; the blank control group (no medication, no drug) was used to determine AFCAMH again. In 60 cases of natural cycle pregnancy, AMH was measured on the 3rd day of menstruation. After 3 months, the AMHs of FSHLH2 were measured again, and the levels of AMH of FSHLH2 / FSHLHG / E2AFCAMH were measured twice before and after the comparison. Results Intra-group comparison: FSHP LH decreased and FSHP / LH increased in FSHP group, but there was a significant increase in AFC in FSHP group, but no significant difference was found in AFC in FSHL group, FSHP LH decreased and AMHAP AFC in FSHP group increased, but AMHAP AFC in FSHP group showed an increasing trend with no statistical significance (P0.05), while in control group, FSHP LHH / FSHP / LH increased in the control group, while in the control group, the level of FSHP / LH increased in the FSHL group, but there was no significant difference in the AFC between the two groups (P < 0 05). There was a significant decrease of AFCU AMH in P0.05 (P 0.05). Comparison between groups: in the blank control group, the level of FSH / LH in FSHLH / FSH / LH was increased, and the AMH of AFCU was significantly decreased (P 0.05) in the control group, but there was no significant difference between the two groups in the FSHLH / LHH / LHH / AFCU AMH group in the FSHLHX / LHX / LHX / AFCU AMH group (P 0.05), while in the FSHL group, there was no significant difference between the two groups (P 0.05). Conclusion Kun Tai capsule can improve ovarian reserve function and help pregnancy.
【作者单位】：山东省潍坊市人民医院生殖医学科;山东省烟台毓璜顶医院;
【分类号】：R711.6

【相似文献】