男性年龄与体外受精-胚胎移植治疗结局的相关性分析

发布时间：2018-05-11 19:27

本文选题：男性年龄 + 精子质量　；参考：《中国性科学》2016年12期

【摘要】：目的:探讨男性年龄对体外受精-胚胎移植(IVF-ET)治疗结局的影响。方法:按照男方年龄将接受常规IVF-ET治疗的188对夫妇分为四组:年龄31岁组53例,31~35岁组78例,36~40岁组37例,40岁组20例。分析男方年龄对IVF-ET治疗结局的影响。结果:本研究中各组间女方年龄、不孕年限、内膜厚度、基础FSH值、Gn总量、获卵总数、MII卵数、可移植胚胎率、优质胚胎率等结果比较均无显著性差异(P0.05),男方精液体积、精子密度、前向运动精子比率均无明显差异(P0.05),36~40岁组(9.3±3.0)和40岁组(9.5±2.6)的正常形态精子比率显著低于31岁组(13.5±2.8)和31~35岁组(12.6±2.7)(P0.05),而且36~40岁组的受精率(76.6%)显著低于31岁组(83.1%)和31~35岁组(81.4%)(P0.05)。另外,31岁、31~35岁、36~40岁、40岁组的着床率分别为:50.91%、41.32%、21.35%、23.4%(P0.05),妊娠率分别为64.15%、62.82%、40.54%、45.0%(P0.05),均呈一定的下降趋势。而各组间的流产率无显著差异(P0.05)。结论:随着年龄的增长,正常形态精子比率及IVF的受精率、胚胎着床率及妊娠率呈现下降的趋势,但仍需进一步的研究。
[Abstract]:Objective: to investigate the effect of male age on the outcome of IVF-ETS. Methods: according to the age of the male, 188 couples who received routine IVF-ET treatment were divided into four groups: 53 cases of age 31 years old group, 78 cases of 35 years old group, 37 cases of 40 years old group and 20 cases of 40 years old group. To analyze the influence of male's age on the outcome of IVF-ET treatment. Results: there were no significant differences in age, infertile years, intimal thickness, total number of basic FSH value (Gn), total number of eggs obtained, transferable embryo rate, rate of high quality embryo, and male semen volume among the three groups. There was no significant difference in sperm density and forward motility spermatozoa ratio between the three groups (P 0.05 卤3.0) and 40 years old (9.5 卤2.6). The normal sperm rate was significantly lower than that of the 31 years old group (13.5 卤2.8) and the 31 35 year old group (12.6 卤2.7 P0.05), and the fertilization rate of the 3640 year old group was significantly lower than that of the 31 year old group (83.1%) and the 31 1 + 35 year old group (81.4%). In addition, the implantation rates of 31 years old and 35 years old and 40 years old group were respectively: 1: 50.91 and 41.32 + 21.35% respectively. The pregnancy rates were 64.15 and 62.822,40.54 respectively, and the pregnancy rates were 64.15, 62.82 and 40.54, respectively, showing a certain downward trend. There was no significant difference in abortion rate among groups (P 0.05). Conclusion: with the increase of age, the rate of normal sperm morphology, fertilization rate of IVF, embryo implantation rate and pregnancy rate are decreasing, but further research is needed.
【作者单位】：北京大学第一医院妇产科;北京大学第一医院泌尿科;
【分类号】：R714.8

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