细胞分化抑制因子-1与细胞增殖核抗原Ki-67在宫颈癌中的表达及相关性研究

发布时间：2018-05-11 20:24

本文选题：宫颈癌 + 细胞分化抑制因子-(Id-)　；参考：《中国临床药理学杂志》2015年08期

【摘要】：目的探讨细胞分化抑制因子-1(Id-1)在宫颈癌、宫颈上皮内瘤变(CIN)及正常宫颈黏膜组织中的表达及临床意义,并评价其与细胞增殖核抗原Ki-67的相关性。方法收集60例宫颈癌、60例CIN及30例正常宫颈黏膜组织,用链霉素亲和生物素-过氧化物酶免疫组化法检测Id-1和Ki-67的表达并进行比较;同时,分析Id-1及Ki-67在宫颈癌中表达的相关性及两者与宫颈癌病理参数的关系。结果 Id-1在正常宫颈黏膜组织、CIN低度病变组织、CIN高度病变组织及宫颈癌组织中的阳性表达率分别为6.67%,10.81%,56.52%,76.67%,差异有统计学意义(P0.05);Ki-67在正常宫颈黏膜组织、CIN低度病变组织、CIN高度病变组织及宫颈癌组织中的阳性表达率分别为10.00%,21.62%,65.21%,80.00%,差异有统计学意义(P0.05)。Id-1和Ki-67的表达与宫颈癌的分化程度、淋巴结转移、脉管浸润及宫颈癌国际妇产科联盟分期呈正相关(P0.05)。结论 Id-1表达上调可能与宫颈癌的发生发展有一定的关系,Id-1、Ki-67蛋白的表达在宫颈癌的发生发展中可能存在一定的协同作用。
[Abstract]:Objective to investigate the expression and clinical significance of cell differentiation inhibitor (ID-1) in cervical carcinoma, cervical intraepithelial neoplasia (cin) and normal cervical mucosa, and to evaluate its correlation with proliferative nuclear antigen (Ki-67). Methods the expressions of Id-1 and Ki-67 were detected by streptomycin affinity biotin peroxidase immunohistochemical method in 60 cases of cervical carcinoma with CIN and 30 cases of normal cervical mucosa. To analyze the correlation between the expression of Id-1 and Ki-67 in cervical carcinoma and the relationship between them and the pathological parameters of cervical cancer. Results the positive expression rates of Id-1 in low grade lesions of cervical mucosa and cervical carcinoma were 6.67 and 10.81, respectively. The difference was statistically significant (P 0.05i 67) in the low grade lesions of cervical mucosa and in the low grade lesions of cervix. The positive rates of Id-1 were 6.67 and 10.81and 56.52and 76.67, respectively. The difference was significant in the tissues with low grade lesions of cin in normal cervical mucosal tissues. The positive expression rates of P0.05, Id-1 and Ki-67 in highly diseased tissues and cervical cancer tissues were 10.00 ~ 21.622 and 65.21, respectively. The difference was statistically significant. Lymph node metastasis, vascular invasion and the staging of International Federation of Obstetrics and Gynecology were positively correlated with P0.05. Conclusion the up-regulation of Id-1 expression may be related to the occurrence and development of cervical carcinoma. The expression of Ki-67 protein may have a synergistic effect on the carcinogenesis and development of cervical carcinoma.
【作者单位】：临海市妇幼保健院妇产科;温州医科大学附属第一医院妇产科;浙江省台州医院妇产科;
【分类号】：R737.33

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