CD138对不孕合并慢性子宫内膜炎的诊断价值及其相关因素分析

发布时间：2018-05-12 01:08

本文选题：慢性子宫内膜炎 + CD　；参考：《中山大学学报(医学科学版)》2015年04期

【摘要】：【目的】探讨CD138免疫组化在慢性子宫内膜炎(CE)诊断中的作用,及助孕患者合并CE的高危因素。【方法】选取93例检查证实为正常宫腔形态,准备行助孕治疗的患者为研究对象,取子宫内膜组织进行常规HE染色和CD138免疫组化染色,同时收集患者病史、跟踪其生殖预后。【结果】1CE的检出率:CD138免疫组化高于HE染色(27.96%vs 26.89%,P0.05);2妊娠率:CD138阳性患者(7.7%)比CD138阴性患者(31.3%)低(P=0.017);3单因素分析结果表明既往有月经淋漓不尽史、人流史及合并有输卵管堵塞等与CE有一定联系(P0.05),Logistic回归分析结果证实月经淋漓不尽(P=0.014,OR=5.394,95%CI1.405-20.699),既往人流史(P=0.029,OR=3.194,95%CI1.125-9.073)、输卵管堵塞(P=0.028,OR=3.274,95%CI1.139-9.415)是CD138阳性的独立危险因素。【结论】CD138免疫组化可提高CE诊断率,既往淋漓不尽病史、人流史输卵管堵塞病史是慢性子宫内膜炎的高危因素,应建议其进行CD138免疫组化检测。
[Abstract]:[objective] to investigate the role of CD138 immunohistochemistry in the diagnosis of chronic endometritis and the high risk factors of CE in pregnant patients. Endometrial tissues were collected for routine HE staining and CD138 immunohistochemical staining. [results] the positive rate of 1CE was 27.96% higher than that of HE staining (27.96 vs 26.89%). The pregnancy rate of patients with positive CD138 CD138 was lower than that of patients with negative CD138. The results of univariate analysis showed that there was no history of menstruation. Logistic regression analysis showed that the history of abortion and the combination of tubal blockage and CE were independent risk factors of CD138 positive. [conclusion] CD138 immunohistochemistry can improve the diagnostic rate of CD138. [conclusion] Immunohistochemistry of CD138 can improve the diagnostic rate of CE. The history of tubal obstruction is a high risk factor for chronic endometritis. It should be suggested that CD138 immunohistochemistry should be performed.
【作者单位】：中山大学附属第一医院妇产科;中山大学附属第一医院病案管理科;中山大学附属第一医院病理科;
【基金】：广东省科技计划项目(2013B021800237、2012B040304007) 广州市科技计划项目(201300000169)
【分类号】：R711.74

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