孕妇巨细胞病毒感染载量与胎儿宫内感染的相关性分析

发布时间：2018-05-12 04:30

本文选题：巨细胞病毒 + 胎儿宫内感染　；参考：《中华医院感染学杂志》2015年15期

【摘要】：目的观察孕妇巨细胞病毒感染载量与胎儿宫内感染的相关性,为减少缺陷儿的出生提供参考依据。方法 2011年1月-2014年1月采用聚合酶链反应方法(PCR)定量检测1 025例孕妇血清中巨细胞病毒的含量,并采用Bayley婴幼儿发育量表(BSID)分析新生儿的发育情况,数据采用SPSS 17.0软件进行统计分析。结果 1 025例孕妇中检出巨细胞病毒感染113例,感染率为11.0%;97例孕妇具有异常妊娠史,检出活动性感染26例,感染率为26.8%,明显高于无异常妊娠史孕妇的巨细胞病毒感染率9.5%,差异有统计学意义(P0.05);巨细胞病毒载量检测3、4级孕妇宫内感染率为87.9%,明显高于0~2级孕妇的17.2%,差异有统计学意义(P0.05);先天性感染MDI、PDI评分明显低于正常儿童,差异有统计学意义(P0.05)。结论孕妇体内高载量的巨细胞病毒感染是造成胎儿宫内感染的重要原因,也是导致新生儿发育不良的重要因素,临床应做好相关防护工作。
[Abstract]:Objective to observe the correlation between the load of cytomegalovirus (CMV) and fetal intrauterine infection in order to reduce the birth of defective infants. Methods from January 2011 to January 2014, serum cytomegalovirus (CMV) levels in 1 025 pregnant women were quantitatively detected by polymerase chain reaction (PCR), and the development of neonates was analyzed by Bayley Infant Development scale (Bayley). The data were analyzed by SPSS 17.0 software. Results 113 cases of cytomegalovirus infection were detected in 1 025 pregnant women, the infection rate was 11.0% and 97 cases had abnormal pregnancy history, 26 cases of active infection were detected. The infection rate of cytomegalovirus was significantly higher than that of pregnant women with no abnormal pregnancy history (P 0.05), and the intrauterine infection rate of pregnant women of grade 3 was 87.9, which was significantly higher than that of pregnant women of grade 0 or 2 (P 0.05). The score of PDI of congenital infection was significantly lower than that of normal children. The difference was statistically significant (P 0.05). Conclusion High load cytomegalovirus infection in pregnant women is an important cause of fetal intrauterine infection and an important factor of neonatal dysplasia.
【作者单位】：平顶山市第一人民医院产科;郑州大学第一附属医院产科;
【基金】：河南省教育厅科学技术研究基金资助项目(12B210009)
【分类号】：R714.251

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