STAT3及其磷酸化蛋白在复发性流产中的作用

发布时间：2018-05-12 22:15

本文选题：信号传导子和转录活化子 + 磷酸化蛋白　；参考：《广东医学》2015年23期

【摘要】：目的探讨STAT33及其磷酸化蛋白(p-STAT3)在人类不明原因复发性流产中的作用。方法采用Western blot法、免疫组化检测20例原因不明的复发性流产患者(流产组)及20例行人工流产正常妊娠妇女(正常组)蜕膜中STAT3及其磷酸化p-STAT3分子的表达。结果流产组STAT3蛋白表达水平与正常组比较差异无统计学意义(P0.05),流产组p-STAT3蛋白表达水平与正常组比较差异有统计学意义(P0.05),而流产组p-STAT3/STAT3比值明显高于正常组(P0.05)。结论 STAT3蛋白在人类不明原因的复发性流产患者的蜕膜组织中均有表达,但STAT3的磷酸化蛋白p-STAT3及p-STAT3/STAT3在复发性流产患者中明显升高,STAT3磷酸化蛋白表达水平升高可能参与了复发性流产的发病机制。
[Abstract]:Objective to investigate the role of STAT33 and its phosphorylated protein p-STAT 3 in recurrent abortion with unknown causes. Methods the expression of STAT3 and phosphorylated p-STAT3 in decidua of 20 patients with recurrent abortion with unknown cause (abortion group) and 20 normal pregnant women with induced abortion (normal group) were detected by Western blot immunohistochemical method. Results there was no significant difference in the expression of STAT3 protein between the abortion group and the normal group (P 0.05). The expression of p-STAT3 protein in the abortion group was significantly higher than that in the normal group (P 0.05), but the p-STAT3/STAT3 ratio in the abortion group was significantly higher than that in the normal group (P 0.05). Conclusion STAT3 protein is expressed in decidual tissues of patients with recurrent abortion of unknown cause. However, the increased expression of phosphorylated protein p-STAT3 and p-STAT3/STAT3 of STAT3 in recurrent abortion may be involved in the pathogenesis of recurrent abortion.
【作者单位】：广西医科大学第一附属医院生殖中心;
【基金】：国家自然科学基金资助项目(编号:81360101)
【分类号】：R714.21

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