胚胎质量对冻融周期中生化妊娠和胚胎早期停止发育的影响

发布时间：2018-05-13 02:37

本文选题：胚胎质量及评分 + 囊胚　；参考：《上海交通大学学报(医学版)》2017年03期

【摘要】：目的·探讨在体外受精-胚胎移植冻融周期中,胚胎的质量是否会影响临床结局导致生化妊娠或早期胚胎停止发育。方法·回顾性分析2015年1月至2016年6月在上海交通大学医学院附属瑞金医院生殖中心行冻融胚胎移植治疗后生化妊娠的115个周期、早期胚胎停止发育的64个周期、继续妊娠的871个周期的临床资料,比较移植后第3天(D3)胚胎质量及评分和囊胚发育速度、囊胚级别在3组之间的差异。结果·在男女双方年龄、不孕年限、排卵日子宫内膜厚度、移植日雌二醇和孕酮水平等方面3组之间比较,差异无统计学意义(P0.05)。多数D3冻融胚的评分为6~8分,且各分值所占比例在3组之间比较,差异无统计学意义(P0.05)。3组中移植的D5囊胚所占的比例均高于D6囊胚所占的比例,但3组之间比较,差异无统计学意义(P0.05)。评级为A、B的囊胚内细胞团比例和评级为C的囊胚内细胞团比例在3组中分别比较,差异均无统计学意义;但在胚胎停止发育组中,评级为C的囊胚滋养层所占的比例为52.2%,明显高于生化妊娠组(35%)和继续妊娠组(29.3%)中相应的比例,且差异均有统计学意义(P0.05)。结论·胚胎质量与生化妊娠没有必然关系,而囊胚滋养层的评级可能是胚胎早期停止发育的主要原因之一。
[Abstract]:Objective to investigate whether the quality of the embryo could affect the clinical outcome and lead to the stop development of biochemical pregnancy or early embryo during the period of in vitro fertilization and embryo transfer. Methods: a retrospective analysis of the biochemical pregnancy after the treatment of frozen thawing embryo transfer in Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine from January 2015 to June 2016. 115 cycles, early embryos stop 64 cycles of development, continue the 871 cycles of pregnancy clinical data, compare the third days after transplantation (D3) embryo quality and score and blastocyst development speed, the difference between the blastocyst grade between the 3 groups. Results: in both men and women age, infertile years, ovulation day endometrium thickness, transplantation day estradiol and progesterone. The difference between the 3 groups was not statistically significant (P0.05). The scores of most D3 freeze-thaw embryos were 6~8 points, and the proportion of each score was compared between the 3 groups, the difference was not statistically significant (P0.05) the proportion of D5 blastocysts in the.3 group was higher than the proportion of the D6 blastocysts, but there was no statistical difference between the 3 groups (P0.05). The proportion of cell mass in the blastocyst of B and the proportion of cell groups rated as C in the 3 groups were not statistically significant in the 3 groups, but the proportion of the blastocyst trophoblast rated as C in the embryonic development group was 52.2%, significantly higher than the proportion in the biochemical pregnancy group (35%) and the continued pregnancy group (29.3%), and the difference was significantly different. There were statistical significance (P0.05). Conclusion: the quality of embryo is not necessarily related to the biochemical pregnancy, but the grading of the blastocyst trophoblast may be one of the main reasons for the early embryonic development.

【作者单位】：上海交通大学医学院附属瑞金医院生殖医学中心;
【基金】：国家自然科学基金(81300548,81370763)~~
【分类号】：R714.8

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