2种瘢痕子宫中期妊娠引产方式疗效比较的系统评价

发布时间：2018-05-13 09:40

  本文选题：瘢痕子宫 + 中期妊娠　； 参考：《重庆医科大学》2014年硕士论文

【摘要】：目的系统评价目前主要采用的2种瘢痕子宫中期妊娠引产方法的疗效。 方法计算机检索MEDLINE、EMbase、万方、维普和CNKI，检索时限均从建库至2013年11月，纳入关于瘢痕子宫中期妊娠引产且引产方法包括米非司酮联合米索前列醇及米非司酮联合依沙吖啶2种方法的随机对照试验，进行文献筛选及质量评价，采用RevMan5.2软件进行统计分析。 结果共纳入8篇文献，文献质量评价根据Jadad量表评分标准。Meta分析结果表明，，米非司酮联合依沙吖啶组（试验组）与米非司酮联合米索前列醇（对照组）相比，能明显缩短宫缩发动时间（P0.00001，WMD=-12.60，95%CI[-17.17,-8.03]）及引产总时间（P=0.0005，WMD=-10.50，95%CI[-16.46,-4.55]），降低胎盘胎膜残留率（Z=3.07，P=0.002，95%CI[0.37,0.80]）、增高引产成功率（P=0.02，Z=2.31，95%CI[0.19,0.88]），但2组在总产程（P=0.10，WMD=-2.16，95%CI[-4.73,0.42]）及产后24小时内阴道出血量（P=0.11， WMD=-29.01，95%CI[-64.12,6.09]）差异均无统计学意义。 结论米非司酮联合依沙吖啶用于瘢痕子宫中期妊娠引产在宫缩发动时间、引产总时间、胎盘胎膜残留率及引产成功率方面均优于米非司酮联合米索前列醇，但前者在引产总产程及产后24小时内阴道出血量方面未显示明显优势。
[Abstract]:Objective to evaluate the efficacy of two main methods of inducing labor in the second trimester of cicatricial uterus. Methods MEDLINE EMbase, Wanfang, Weip and CNKI were searched by computer. A randomized controlled trial was conducted on the methods of induced labor and induced labor in the second trimester of cicatricial uterus, including mifepristone combined with misoprostol and mifepristone combined with ethacridine, for literature screening and quality evaluation. RevMan5.2 software was used for statistical analysis. Results A total of 8 articles were included. According to the Jadad scale, the results of Meta-analysis showed that mifepristone combined with ethacridine (trial group) was compared with mifepristone combined with misoprostol (control group). 鑳芥槑鏄剧缉鐭�瀹�缂╁彂鍔ㄦ椂闂

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