早期宫颈癌前哨淋巴结微转移检测方法及临床意义的研究进展

发布时间：2018-05-13 13:30

本文选题：宫颈癌 + 前哨淋巴结　；参考：《南昌大学》2017年硕士论文

【摘要】：宫颈癌是女性第二常见的恶性肿瘤,发病率仅次于乳腺癌,且存在年青化趋向。淋巴结转移状况是评估宫颈癌预后的独立危险因素,也是指导术后辅助治疗的重要参考依据。前哨淋巴结检测作为一种淋巴结转移的筛选手段,广泛用于乳腺癌诊疗中,近年被试用于宫颈癌,原因是广泛性子宫切除+盆(腹)腔淋巴结清除(RHPLND)是早期宫颈浸润癌的常用术式,而数据却显示早期宫颈癌的淋巴转移率并不高,大部分早期宫颈癌患者被实施了不必要的系统性淋巴结清除,且有部分患者承受其带来的相关并发症。前哨淋巴结微转移指前哨淋巴结内常规病理学不能检出的微小转移灶及散播肿瘤细胞,目前在宫颈癌诊疗中的意义尚未完全阐明,其检测作为淋巴结转移状态的一种诊断技术,可提高宫颈癌前哨淋巴结检测的准确性,旨在准确评估早期宫颈癌患者的淋巴结转移状态,精准指导早期宫颈癌的个体化治疗,但目前其检测方法和意义均未得到大量数据证实,本文根据检索各数据库的相关文献,就早期宫颈癌前哨淋巴结微转移检测方法以及临床意义研究的最新进展加以综述。
[Abstract]:Cervical cancer is the second most common malignant tumor in women. Lymph node metastasis is an independent risk factor for the prognosis of cervical cancer and an important reference for guiding postoperative adjuvant therapy. As a screening method for lymph node metastasis, sentinel lymph node detection is widely used in the diagnosis and treatment of breast cancer. The reason is that extensive hysterectomy of pelvic (abdominal) cavity lymphadenectomy is a common procedure for early invasive carcinoma of the cervix, but the data show that the lymphatic metastasis rate of early cervical cancer is not high. Most patients with early cervical cancer undergo unnecessary systemic lymphadenectomy, and some of them suffer associated complications. Sentinel lymph node micrometastasis refers to the small metastatic foci and tumor spreading cells which cannot be detected by routine pathology in sentinel lymph nodes. The significance of micrometastasis in diagnosis and treatment of cervical cancer has not been fully clarified at present. The detection of micrometastasis in sentinel lymph nodes is regarded as a diagnostic technique for lymph node metastasis. It can improve the accuracy of sentinel lymph node detection in cervical cancer. It aims to accurately evaluate the status of lymph node metastasis in patients with early cervical cancer and guide the individualized treatment of early cervical cancer. However, the methods and significance of detection have not been confirmed by a large number of data. In this paper, the methods of detection of sentinel lymph node micrometastasis in early cervical cancer and the latest research progress of clinical significance are reviewed according to the relevant literatures in various databases.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.33

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