血清STMN1、OPN联合检测在宫颈癌淋巴结转移诊断中的价值

发布时间：2018-05-13 22:23

本文选题：微管解聚蛋白 + 骨桥蛋白　；参考：《山东医药》2015年46期

【摘要】：目的探讨血清微管解聚蛋白(STMN1)及骨桥蛋白(OPN)联合检测在宫颈癌淋巴结转移诊断中的价值。方法 96例宫颈癌患者根据是否出现淋巴结转移分为淋巴结转移27例(A组)与无淋巴转移69例(B组),采用酶联免疫吸附法检测血清STMN1及OPN。结果 A组和B组血清STMN1的阳性率分别为88.89%(24/27)、69.56%(48/69),P0.05;A组和B组血清OPN的阳性率分别为96.29%(26/27)、68.11%(47/69),P0.05。STMN1和OPN诊断宫颈癌淋巴结转移的敏感度分别为88.89%、96.29%,二者联合检测敏感度为100%。结论血清STMN1及OPN联合检测有助于宫颈癌淋巴结转移的诊断。
[Abstract]:Objective to investigate the value of serum microtubule depolymerization protein (STMN 1) and osteopontin (OPN) in the diagnosis of cervical cancer lymph node metastasis. Methods Ninety-six patients with cervical cancer were divided into two groups according to whether lymph node metastasis occurred or not. There were 27 cases of lymph node metastasis in group A and 69 cases in group B without lymph node metastasis. Serum STMN1 and OPN were detected by enzyme-linked immunosorbent assay (Elisa). Results the positive rates of serum STMN1 in group A and group B were 88.89 / 24 / 27 and 69.56, respectively. The positive rates of serum OPN in group A and group B were 96.292626 / 27 and 68.110.47 / 69 respectively, and the sensitivity of diagnosis of lymph node metastasis of cervical cancer by OPN and STMN1 were 88.8996.299.290.The sensitivity of the combined detection was 100. Conclusion the combined detection of serum STMN1 and OPN is helpful for the diagnosis of lymph node metastasis of cervical cancer.
【作者单位】：聊城市第二人民医院;
【基金】：山东省聊城市卫生局立项课题([2014]2-149)
【分类号】：R737.33

【参考文献】