黏蛋白1和整合素β3在子痫前期患者胎盘中的表达及相关性

发布时间：2018-05-14 10:16

本文选题：黏蛋白 + 整合素β　；参考：《中国妇产科临床杂志》2015年06期

【摘要】：目的研究子痫前期(preeclampsia,PE)患者胎盘组织中的黏蛋白1(MUC1)、整合素β3(Integrinβ3)的表达情况,探讨二者在子痫前期胎盘中的作用。方法采用蛋白质印迹法检测子痫前期轻度组(轻度PE组,20例)、重度组(重度PE组,20例)和正常妊娠组(正常组,20例)胎盘组织中MUC1和Integrinβ3蛋白的表达。结果 1 MUC1在正常组,轻度PE组和重度PE组胎盘组织中相对表达量分别为0.53±0.13、0.56±0.12和0.90±0.20,轻、重度PE组均明显高于正常组(P0.05);2正常组、轻度和重度PE组胎盘组织中Integrinβ3的相对表达量分别为0.61±0.14、0.57±0.13和0.51±0.12,轻、重度PE组表达均低于正常组(P0.05);3 MUC1与Integrinβ3在子痫前期患者胎盘中的表达呈负相关(r=-0.79,P0.05)。结论 MUC1蛋白在子痫前期的表达随病情加重而增加,Integrinβ3蛋白的表达随病情的加重而降低,二者可能共同参与子痫前期发病。
[Abstract]:Objective to study the expression of mucin 1 (MUC1) and integrin 尾 3(Integrin 尾 3 (integrin 尾 3(Integrin 尾 3) in placenta of preeclampsis (PEP) patients, and to explore their roles in the placenta of preeclampsia. Methods the expression of MUC1 and Integrin 尾 3 protein in placenta of mild preeclampsia group (20 cases of mild PE group), severe group (20 cases of severe PE group) and normal pregnancy group (20 cases of normal pregnancy group) were detected by Western blot. Results 1the relative expression of MUC1 in placenta of normal group, mild PE group and severe PE group were 0.53 卤0.130.56 卤0.12 and 0.90 卤0.20, respectively. The relative expression levels of Integrin 尾 3 in placenta of mild and severe PE groups were 0.61 卤0.14 0.57 卤0.13 and 0.51 卤0.12, respectively. The expression of Integrin 尾 3 in severe PE group was lower than that in normal group. The expression of Integrin 尾 3 in placenta of preeclampsia group was negatively correlated with that of Integrin 尾 3 expression in placenta of preeclampsia patients. Conclusion the expression of MUC1 protein in preeclampsia increases with the severity of preeclampsia, and the expression of integrin 尾 3 protein decreases with the severity of the disease. Both of them may be involved in the pathogenesis of preeclampsia.
【作者单位】：赤峰生殖健康专科医院生殖医学中心;内蒙古医科大学附属医院妇产科;
【分类号】：R714.244

【参考文献】