B族链球菌产前筛查在母婴感染防控中的应用

发布时间：2018-05-14 11:02

本文选题：妊娠晚期 + B族链球菌　；参考：《检验医学》2016年04期

【摘要】：目的建立产前筛查B族链球菌(GBS)检验方法,将其应用于孕晚期GBS携带的筛查,探讨妊娠晚期对孕妇进行GBS感染筛查的临床意义,并对GBS带菌者采取干预措施,观察其对母婴感染的防控作用。方法选取产科进行产前检查及分娩的35周以上的孕妇1 000例为研究对象,采集孕妇阴道口1/3处及肛周分泌物进行GBS筛查,采用已建立的细菌培养法检测GBS,将GBS阳性者根据其意愿分为干预治疗组和不干预治疗组,干预治疗组在临产后或破膜后预防性应用抗菌药物,不干预治疗组不作处理。对比各组产妇的妊娠结局。结果 1 000例受检孕妇经检测共发生GBS感染97例,感染率为9.7%;与GBS阴性组相比,干预治疗组胎膜早破、早产、宫内感染、胎儿窘迫、新生儿低体质量、Apgar评分及感染发生率差异均无统计学意义(P0.05);而与不干预治疗组相比,干预治疗组Apgar评分差异无统计学意义(P0.05),其他指标差异均有统计学意义(P0.05)。结论建立的筛查GBS方法可快速、敏感、特异地筛查出孕妇阴道及肛周样本中的GBS。孕晚期对孕妇进行GBS感染的筛查非常重要,及时采取干预措施可有效减少不良妊娠结局及母婴感染的发生率。
[Abstract]:Objective to establish a prenatal screening method for B Streptococcus (GBS), and to apply it to the screening of GBS in the late pregnancy, to explore the clinical significance of GBS infection screening for pregnant women in the late pregnancy, and to take intervention measures for the GBS carriers to observe the prevention and control of maternal and infant infection. The method of obstetrics was selected for prenatal examination and more than 35 weeks of childbirth. 1000 cases of pregnant women were studied. GBS screening of 1/3 and perianal secretion of pregnant women was collected. The established bacterial culture method was used to detect GBS. The GBS positive people were divided into the intervention treatment group and the non intervention group according to their wishes. The intervention treatment group was used to prevent the antibiotics after the delivery or after the rupture of the membrane. No intervention treatment group was not used. Results 1000 cases of pregnant women received GBS infection in 97 cases, the infection rate was 9.7%, compared with the GBS negative group, the intervention group had no significant difference between the premature rupture of the membranes, the premature birth, the intrauterine infection, the fetal distress, the low body mass of the newborn, the Apgar score and the incidence of infection. There was no significant difference in Apgar score in intervention treatment group (P0.05), and there were significant differences in other indicators (P0.05). Conclusion the established screening GBS method can be quickly, sensitive and specific screening of pregnant women in the vaginal and anal weeks of pregnant women in the late GBS. pregnancy screening for pregnant women to carry out GBS infection screening is very important, timely take dry. Pre measures can effectively reduce adverse pregnancy outcomes and the incidence of maternal and infant infections.

【作者单位】：金华市人民医院;金华市婺城区妇幼保健院;金华市职业技术学院;
【基金】：2014年金华市科技计划项目(2014-3-067)
【分类号】：R714.251;R446.5

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